Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1, -4, -5, and -11 are …

Neutrophil extrusion of neutrophil extracellular traps (NETs) and concomitant cell death (NETosis)
provides host defense against extracellular pathogens, whereas macrophage death …

IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine.
Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-…

Innate immune cells such as macrophages and neutrophils initiate protective inflammatory
responses and engage antimicrobial responses to provide frontline defence against invading …

Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we
identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible …

Caspase-11 is a cytosolic sensor and protease that drives innate immune responses to the
bacterial cell wall component, LPS. Caspase-11 provides defence against cytosolic Gram-…

The noncanonical inflammasome is a signalling complex critical for cell defence against
cytosolic Gram-negative bacteria. A key step in the human noncanonical inflammasome …

Apoptosis is traditionally considered to be an immunologically silent form of cell death.
Multiple mechanisms exist to ensure that apoptosis does not stimulate the immune system to …

Bacteria that occupy an intracellular niche can evade extracellular host immune responses
and antimicrobial molecules. In addition to classic intracellular pathogens, other bacteria …

The mammalian inhibitor of apoptosis proteins (IAPs) are key regulators of cell death and
inflammation. A major function of IAPs is to block the formation of a cell death–inducing …