With the spreading of antibiotic resistance, the translocation of antibiotics through bacterial
envelopes is crucial for their antibacterial activity. In Gram-negative bacteria, the interplay …

The efficacy of antibacterial molecules depends on their capacity to reach inhibitory concentrations
in the vicinity of their target. This is particularly challenging for drugs directed against …

… MR and J.-MP designed the research. JV, ED, BC, LM, and EB performed the various
chemical … MM, MR and J.-MP supervised the overall project and wrote the manuscript with …

Nanocomposites of electroactive ceramics and ferroelectric polymers exploit favorable features
of the matrix polymer and the nanostructured filler to produce new functional materials for …

Biocompatible fluorescent nanostructures were prepared by a functionalization of gold
nanoparticles with the amino acid tryptophan. The gold-tryptophan bioconjugates were …

Background In Gram-negative bacteria, passing through the double membrane barrier to
reach the inhibitory concentration inside the bacterium is a pivotal step for antibiotic activity. …

Gold nanoparticles were functionalized by amino acid tryptophan and vitamin riboflavin - a
resonance energy transfer (RET) pair of biomolecules. The presence of the gold …

A main challenge in chemotherapy is to determine the in cellulo parameters modulating the
drug concentration required for therapeutic action. It is absolutely urgent to understand …

Sufficient concentration of antibiotics close to their target is key for antimicrobial action. Among
the tools exploited by bacteria to reduce the internal concentration of antibiotics, multidrug …

To understand antibiotic resistance in Gram-negative bacteria, a key point is to investigate
antibiotic accumulation, which is defined by influx and efflux. Several methods exist to …