Sclerostin is an osteocyte‐derived negative regulator of bone formation. It inhibits BMP‐stimulated
bone formation both in vitro and in vivo but has no direct effect on BMP signaling. …

The long-term health outcome of prenatal exposure to arsenic has been associated with
increased mortality in human populations. In this study, the extent to which maternal arsenic …

To date, cross-species comparisons of genetic interactomes have been restricted to small or
functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a …

A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on
antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular complexes …

Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions. …

Transcriptionally active and inactive chromatin domains tend to segregate into separate sub-nuclear
compartments to maintain stable expression patterns. However, here we uncovered …

10.7554/eLife.34655.001 Human immunodeficiency virus (HIV) infection is currently incurable,
due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure …

Nucleosome positioning governs access to eukaryotic genomes. Many genes show a
stereotypic organisation at their 5′end: a nucleosome free region just upstream of the …

Background Radiation is an effective anti-cancer therapy but leads to severe late radiation
toxicity in 5%–10% of patients. Assuming that genetic susceptibility impacts this risk, we …

Specialized chromatin containing CENP-A nucleosomes instead of H3 nucleosomes is found
at all centromeres. However, the mechanisms that specify the locations at which CENP-A …