daf-16 is a forkhead-type transcription factor, functioning downstream of insulin-like signals,
and is known to be critical to the regulation of life span in Caenorhabditis elegans. …

Extracellular matrix (ECM), which provides critical scaffolds for all adhesive cells, regulates
proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs, …

ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs)-like (ADAMTSL)
proteins, a subgroup of the ADAMTS superfamily, share several domains with ADAMTS …

Background: Polydom/SVEP1 is a putative extracellular matrix protein of unknown function.
Results: Polydom/SVEP1 is a potent ligand for integrin α9β1 and colocalizes with the integrin …

Rationale: Lymphatic vasculature constitutes a second vascular system essential for immune
surveillance and tissue fluid homeostasis. Maturation of the hierarchical vascular structure, …

Activin A, a member of the transforming growth factor-β family, plays important roles in
hormonal homeostasis and embryogenesis. In this study, we produced recombinant human …

Dysfunction of the basement membrane protein QBRICK provokes Fraser syndrome, which
results in renal dysmorphogenesis, cryptophthalmos, syndactyly, and dystrophic …

Free radicals and lipid peroxide (LPO), easily formed in the diabetic state, play an important
role in the development of diabetic complications. Potentially, nicorandil may reduce the …

The niche is a specialized microenvironment for tissue stem cells in vivo. It has long been
emphasized that niche ECM molecules act on tissue stem cells to regulate their behavior, but …

Nephronectin is a basement membrane protein comprising five N-terminal epidermal growth
factor (EGF)-like repeats, a central linker segment containing an Arg-Gly-Asp (RGD) motif …