User profiles for Iswar K Hariharan

Iswar Hariharan

University of California, Berkeley
Verified email at berkeley.edu
Cited by 12390

Comparative genomics of the eukaryotes

…, GL Gabor, Miklos, CR Nelson, IK Hariharan… - Science, 2000 - science.org
A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis
elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was …

[HTML][HTML] The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

KF Harvey, CM Pfleger, IK Hariharan - Cell, 2003 - cell.com
Establishing and maintaining homeostasis is critical to the well-being of an organism and is
determined by the balance of cell proliferation and death. Two genes that function together …

[HTML][HTML] salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

…, DCR Wahrer, TA Schiripo, DA Haber, IK Hariharan - Cell, 2002 - cell.com
The number of cells in an organism is determined by regulating both cell proliferation and
cell death. Relatively few mechanisms have been identified that can modulate both of these …

[HTML][HTML] The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

N Tapon, N Ito, BJ Dickson, JE Treisman, IK Hariharan - Cell, 2001 - cell.com
The inherited human disease tuberous sclerosis, characterized by hamartomatous tumors,
results from mutations in either TSC1 or TSC2. We have characterized mutations in the …

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

…, DW Bell, DCR Wahrer, DA Haber, IK Hariharan - Nature, 2001 - nature.com
During Drosophila development and mammalian embryogenesis, exit from the cell cycle is
contingent on tightly controlled downregulation of the activity of Cyclin E–Cdk2 complexes …

[HTML][HTML] A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis

JC de Nooij, MA Letendre, IK Hariharan - Cell, 1996 - cell.com
In a screen for genes that interact with the Rap1 GTPase, we have identified a Drosophila
gene, dacapo (dap), which is a member of the p21/p27 family of cdk inhibitors. Unlike …

[PDF][PDF] Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth

KH Moberg, S Schelble, SK Burdick, IK Hariharan - Developmental cell, 2005 - cell.com
The reproducible pattern of organismal growth during metazoan development is the product
of genetically controlled signaling pathways. Patterned activation of these pathways shapes …

A Survey of Human Disease Gene Counterparts in the Drosophila Genome

…, MP Skupski, MS Boguski, IK Hariharan - The Journal of cell …, 2000 - rupress.org
The recent sequencing of the Drosophila genome as a collaborative effort between the
Berkeley Drosophila Genome Project (BDGP) 1 and Celera Genomics provides an unparalleled …

[PDF][PDF] Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc

RK Smith-Bolton, MI Worley, H Kanda, IK Hariharan - Developmental cell, 2009 - cell.com
The study of regeneration would be aided greatly by systems that support large-scale
genetic screens. Here we describe a nonsurgical method for inducing tissue damage and …

Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila

IK Hariharan, D Bilder - Annu. Rev. Genet., 2006 - annualreviews.org
Inactivating mutations in the Drosophila tumor-suppressor genes result in tissue overgrowth.
This can occur because the mutant tissue either grows faster than wild-type tissue and/or …