Aims Women with aortic stenosis develop a more concentric form of LV hypertrophy than
men. However, the molecular factors underlying sex differences in LV remodelling are …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …

Objectives : This study investigated the effects of 17β-estradiol (E2) on gene regulation in
human cardiac tissues. We hypothesized that a candidate E2 effect is cardiomyocyte (CM)- …

Aims Atrial fibrillation (AF) prevalence increases with advanced stages of left ventricular (LV)
dysfunction. Remote proarrhythmic effects of ventricular dysfunction on atrial …

Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐cardiac
compounds and may lead to the development of life‐threatening Torsades de Pointes (…

Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Purpose Aging has severe implications for tissue damage and is a major risk factor for
disease. However, the effects of aging on cardiac extracellular matrix (ECM) components in …

Background— Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase effectiveness …

Linked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may
lead to dilated cardiomyopathy. Although sex and age differences in the development of …

Aging is associated with increased inflammation and alterations in mitochondrial biogenesis,
which promote the development of cardiovascular diseases. Emerging evidence suggests …