Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

…, M Benkißer-Petersen, I Wilhelm… - Blood, The Journal …, 2015 - ashpublications.org
B-cell antigen receptor (BCR) expression is a key feature of most B-cell lymphomas, but the
mechanisms of BCR signal induction and the involvement of autoantigen recognition remain …

Gb3-binding lectins as potential carriers for transcellular drug delivery

SK Müller, I Wilhelm, T Schubert, K Zittlau… - Expert opinion on …, 2017 - Taylor & Francis
Objectives: Epithelial cell layers as well as endothelia forming the blood-brain barrier can
drastically reduce the efficiency of drug targeting. Our goal was to investigate lectins …

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

I Wilhelm, E Levit-Zerdoun, J Jakob, S Villringer… - Science …, 2019 - science.org
Bacterial lectins are typically multivalent and bind noncovalently to specific carbohydrates
on host tissues to facilitate bacterial adhesion. Here, we analyzed the effects of two fucose-…

Phlegmatization of TATP and HMTD with activated charcoal as training aid for explosive detection dogs

I Wilhelm, G Bikelytė, M Wittek… - Propellants …, 2022 - Wiley Online Library
Both TATP and HMTD could be phlegmatized by coprecipitation with active charcoal
resulting in mixtures with a nominal content of 40 wt‐% (d40‐TATP) and 10 wt‐% (d10‐HMTD), …

Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signalling

…, T Wolf, C Gretzmeier, I Wilhelm… - Life science …, 2019 - life-science-alliance.org
Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in
nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue …

Survival of Igα-deficient mature b cells requires BAFF-R function

…, M Becker, R Pohlmeyer, I Wilhelm… - The Journal of …, 2016 - journals.aai.org
Expression of a functional BCR is essential for the development of mature B cells and has
been invoked in the control of their maintenance. To test this maintenance function in a new …

[HTML][HTML] Molecularly imprinted sol-gel for TNT detection with optical micro-ring resonator sensor chips

L Eisner, I Wilhelm, G Flachenecker, J Hürttlen… - Sensors, 2019 - mdpi.com
A sensor for trinitrotoluene (TNT) detection was developed by using a combination of optical
micro-ring technology and a receptor coating based on molecularly imprinted sol-gel layers. …

[HTML][HTML] Overall survival and subgroup analysis from a randomized phase III study of intravenous rigosertib versus best supportive care (BSC) in patients (pts) with …

…, LA Godley, R Collins, E Atallah, F Wilhelm, IE Wilhelm… - Blood, 2014 - Elsevier
Background: No approved treatment options are available to HR-MDS pts after HMA therapy.
Study 04-21 (“ONTIME” trial) was a Phase III, randomized, controlled study of the efficacy …

[HTML][HTML] Bacterial lectin BambL acts as a B cell superantigen

…, C Jäger, PF Müller, A Tadić, I Wilhelm… - Cellular and Molecular …, 2021 - Springer
B cell superantigens crosslink conserved domains of B cell receptors (BCRs) and cause
dysregulated, polyclonal B cell activation irrespective of normal BCR-antigen complementarity. …

Novel low-cost selective pre-concentrators based on metal organic frameworks

I Wilhelm, M Rieger, J Hürttlen, M Wittek, C Alépée… - Procedia …, 2016 - Elsevier
Metal organic frameworks (MOFs) are used as selective preconcentrator-materials in order
to improve the overall sensor-system sensitivity. MOFs exhibit interior surface areas of above …