IgG molecules exert both pro- and antiinflammatory effector functions based on the
composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have …

Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …

Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin
gamma (IgG) activates the classical complement pathway and depends on its close …

Immunological memory is a mechanism to protect us against reinfection. Antibodies produced
by B cells are integral to this defense strategy and underlie virtually all vaccine success. …

Germinal centers (GCs), transient structures within B cell follicles and central to affinity
maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell-derived …

Vaccines work largely by generating long-lived plasma cells (LLPCs), but knowledge of how
such cells are recruited is sparse. Although it is clear that LLPCs preferentially originate in …

The human tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated
herpesvirus (KSHV) establish persistent infections in B cells. KSHV is linked to primary effusion …

Owing to its anti-inflammatory efficacy in various autoimmune disease conditions, intravenous
immunoglobulin (IVIG)—pooled IgG obtained from the plasma of several thousands …

Immunoglobulin gamma (IgG) antibodies are key effector proteins of the immune system. They
recognize antigens with high specificity and are indispensable for immunological memory …

Although reactivation and accumulation of autoreactive CD4 + T cells within the CNS are
considered to play a key role in the pathogenesis of multiple sclerosis (MS) and its animal …