User profiles for Ioannis S Pateras

Ioannis Pateras

National and Kapodistrian University of Athens, Medical School, Athens, Greece
Verified email at med.uoa.gr
Cited by 3611

[PDF][PDF] Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer

…, IS Pateras, O Tarcic, H Solomon, AJ Schetter, S Wilder… - Cancer cell, 2013 - cell.com
The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53)
isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We …

[HTML][HTML] Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

T Cooks, IS Pateras, LM Jenkins, KM Patel… - Nature …, 2018 - nature.com
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific
mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of …

[PDF][PDF] Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival

…, A Igea, S Sakellariou, IS Pateras… - Cancer cell, 2014 - cell.com
Colorectal cancer is frequently associated with chronic inflammation, with the intestinal
epithelial barrier playing an important protective role against the infections and injuries that …

p57KIP2: “Kip”ing the Cell under Control

IS Pateras, K Apostolopoulou, K Niforou… - Molecular Cancer …, 2009 - AACR
… oscillations of G and S phases in the … S-entry and reappearing after the completion of S
phase (115). Introduction of a stable form of p57 KIP2 into trophoblast giant cells blocks G1- to S-…

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

IS Pateras, S Havaki, X Nikitopoulou, K Vougas… - Pharmacology & …, 2015 - Elsevier
The characteristic feature of healthy living organisms is the preservation of homeostasis.
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …

[PDF][PDF] RNF20 links histone H2B ubiquitylation with inflammation and inflammation-associated cancer

O Tarcic, IS Pateras, T Cooks, E Shema, J Kanterman… - Cell reports, 2016 - cell.com
Factors linking inflammation and cancer are of great interest. We now report that the
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation (…

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

…, A Dereli-Oz, M Kocylowski, IS Pateras… - Nature cell …, 2013 - nature.com
The DNA damage response (DDR) pathway and ARF function as barriers to cancer development.
Although commonly regarded as operating independently of each other, some studies …

Integrating the DNA damage and protein stress responses during cancer development and treatment

VG Gorgoulis, DE Pefani, IS Pateras… - The Journal of …, 2018 - Wiley Online Library
Ioannis S PaterasIoannis S Pateras … proximal pausing sites maximizes sensing and
accelerates the repair of category-S lesions equally well in genes with low and high expression via …

[HTML][HTML] Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers

H Solomon, N Dinowitz, IS Pateras, T Cooks, Y Shetzer… - Oncogene, 2018 - nature.com
Emerging notion in carcinogenesis ascribes tumor initiation and aggressiveness to cancer
stem cells (CSCs). Specifically, colorectal cancer (CRC) development was shown to be …

[HTML][HTML] Inflammation, DNA damage, Helicobacter pylori and gastric tumorigenesis

P Kalisperati, E Spanou, IS Pateras… - Frontiers in …, 2017 - frontiersin.org
Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of
almost half human population. It has evolved to escape immune surveillance, establishes …