Spindle formation in male meiosis relies on the canonical centrosome system, which is
distinct from acentrosomal oocyte meiosis, but its specific regulatory mechanisms remain …

Multiple pathways regulate the repair of double-strand breaks (DSBs) to suppress potentially
dangerous ectopic recombination. Both sequence and chromatin context are thought to …

Telomeres are nucleoprotein complexes at the ends of chromosomes and are indispensable
for the protection and lengthening of terminal DNA. Despite the evolutionarily conserved …

Terpolymerization of cyclohexene oxide (CHO), CO2, and aryl isothiocyanates produced
poly(carbonate–thioimidocarbonate)s with gradient character, while that of CHO, CO2, and aryl …

Telomere binding protein Stn1 forms the CST (Cdc13/CTC1-STN1-TEN1) complex in budding
yeast and mammals. Likewise, fission yeast Stn1 and Ten1 form a complex indispensable …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation, …

Chromosome fusion is a frequent intermediate in oncogenic chromosome rearrangements
and has been proposed to cause multiple tumor-driving abnormalities. In conventional …

Derivatives of a novel scaffold, C-phenyl 1-thio-d-glucitol, were prepared and evaluated for
sodium-dependent glucose cotransporter (SGLT) 2 and SGLT1 inhibition activities. …

Genomic rearrangements (gross chromosomal rearrangements, GCRs) threatens genome
integrity and cause cell death or tumor formation. At the terminus of linear chromosomes, a …

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective
inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring …