Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell
biology. In blood vessels, disturbed flow is associated with vascular diseases, such as …

We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an
autosomal dominant primary lymphedema associated with a predisposition to acute myeloid …

Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization,
which is generally preceded by neolymphangiogenesis 1 , 2 , 3 . However, sentinel …

Lymphatic vessel growth or lymphangiogenesis occurs during embryonic development and
wound healing and plays an important role in tumor metastasis and inflammatory diseases. …

Rationale: The formation of the blood vasculature is achieved via 2 fundamentally different
mechanisms, de novo formation of vessels from endothelial progenitors (vasculogenesis) and …

Pathological lymphatic diseases mostly affect vessels in specific tissues, yet little is known
about organ-specific regulation of the lymphatic vasculature. Here, we show that the vascular …

Metabolic health depends on the brain’s ability to control food intake and nutrient use versus
storage, processes that require peripheral signals such as the adipocyte-derived hormone, …

We have identified KIF11 mutations in individuals with syndromic autosomal-dominant
microcephaly associated with lymphedema and/or chorioretinopathy. Initial whole-exome …

Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches.
Here we show unexpected effects of incomplete targeting, by demonstrating how …

The CreER T2 /loxP system is widely used to induce conditional gene deletion in mice. One
of the main advantages of the system is that Cre-mediated recombination can be controlled …