User profiles for Ilie-Cosmin Stancu
 | Ilie Cosmin StancuBIOMED, Hasselt University Verified email at uhasselt.be Cited by 1833 |
[HTML][HTML] Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism
IC Stancu, B Vasconcelos, D Terwel… - Molecular …, 2014 - Springer
The amyloid cascade hypothesis has been the prevailing hypothesis in Alzheimer’s Disease
research, although the final and most wanted proof ie fully successful anti-amyloid clinical …
research, although the final and most wanted proof ie fully successful anti-amyloid clinical …
[HTML][HTML] Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
IC Stancu, N Cremers, H Vanrusselt, J Couturier… - Acta …, 2019 - Springer
Brains of Alzheimer’s disease patients are characterized by the presence of amyloid plaques
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial …
and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial …
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
E Peeraer, A Bottelbergs, K Van Kolen, IC Stancu… - Neurobiology of …, 2015 - Elsevier
Neurofibrillary tangles composed of hyperphosphorylated fibrillized tau are found in
numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau …
numerous tauopathies including Alzheimer's disease. Increasing evidence suggests that tau …
[PDF][PDF] Synaptogyrin-3 mediates presynaptic dysfunction induced by tau
…, K Wierda, A Snellinx, L Bounti, YC Wang, IC Stancu… - Neuron, 2018 - cell.com
Synaptic dysfunction is an early pathological feature of neurodegenerative diseases associated
with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may …
with Tau, including Alzheimer's disease. Interfering with early synaptic dysfunction may …
[HTML][HTML] Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau …
Prion-like seeding and propagation of Tau-pathology have been demonstrated experimentally
and may underlie the stereotyped progression of neurodegenerative Tauopathies. …
and may underlie the stereotyped progression of neurodegenerative Tauopathies. …
[HTML][HTML] Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
Genetic, clinical, histopathological and biomarker data strongly support Beta-amyloid (Aβ)
induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in …
induced spreading of Tau-pathology beyond entorhinal cortex (EC), as a crucial process in …
[HTML][HTML] Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer …
Background The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in Alzheimer
disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers …
disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide triggers …
[HTML][HTML] Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo
…, G Joberty, A Buist, A Vanoosthuyse, IC Stancu… - Acta …, 2017 - Springer
Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In
Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal …
Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal …
The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model
IC Stancu, C Lodder, P Botella Lucena, S Vanherle… - Glia, 2022 - Wiley Online Library
An active role of neuroinflammation and the NLRP3 inflammasome in Alzheimer's disease
and related tauopathies is increasingly identified, supporting NLRP3 as an interesting …
and related tauopathies is increasingly identified, supporting NLRP3 as an interesting …
[HTML][HTML] CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated …
C Lodder, I Scheyltjens, IC Stancu… - Acta neuropathologica …, 2021 - Springer
Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A),
neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While …
neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While …