RAS proteins are monomeric GTPases that act as binary molecular switches to regulate a
wide range of cellular processes. The exchange of GTP for GDP on RAS is regulated by …

K-Ras associates with the plasma membrane (PM) through farnesylation that functions in
conjunction with an adjacent polybasic sequence. We show that phosphorylation by protein …

Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers.
We have shown recently that Ras is activated on and transmits signals from the Golgi …

The most frequently mutated oncogene in cancer is KRAS, which uses alternative fourth
exons to generate two gene products (KRAS4A and KRAS4B) that differ only in their C-terminal …

Rap1 and Ras are closely related GTPases that share some effectors but have distinct functions.
We studied the subcellular localization of Rap1 and its sites of activation in living cells. …

A cycle of palmitoylation/depalmitoylation of H-Ras mediates bidirectional trafficking between
the Golgi apparatus and the plasma membrane, but nothing is known about how this cycle …

Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is
critical for modulating adaptive immunity. As such, it has been successfully exploited for cancer …

Nijmegen breakage syndrome (NBS) is a rare human disease displaying chromosome instability,
radiosensitivity, cancer predisposition, immunodeficiency, and other defects [1, 2]. NBS …

A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford
progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the …

Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes.
Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can …