Embryonic stem (ES) cells undergo extended proliferation while remaining poised for
multilineage differentiation. A unique network of transcription factors may characterize self-renewal …

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and
developing germ cells 1 , 2 . Deletion of Nanog causes early embryonic lethality 2 , whereas …

Pluripotent stem cells derived from preimplantation embryos, primordial germ cells or
teratocarcinomas are currently unique in undergoing prolonged symmetrical self-renewal in culture…

Pluripotency is generated naturally during mammalian development through formation of the
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell …

Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ
cells. We report that the activity of Oct4 is essential for the identity of the pluripotential founder …

A fundamental goal in biology is to understand the molecular basis of cell identity. Pluripotent
embryonic stem (ES) cell identity is governed by a set of transcription factors centred on …

Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog
expression. However, the mechanisms by which Nanog functions remain unclear, and in particular…

The cytokine leukemia inhibitory factor (LIF) drives self-renewal of mouse embryonic stem (ES)
cells by activating the transcription factor STAT3. In serum-free cultures, however, LIF is …

The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is
dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through …

The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals
transduced through the cytokine receptor subunit gp130. Signalling molecules activated …