[HTML][HTML] YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

…, N Fernández-Borges, IM Vorberg… - Molecular …, 2017 - Springer
Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by
inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 …

[HTML][HTML] Viruses in neurodegenerative diseases: More than just suspects in crimes

P Leblanc, IM Vorberg - PLoS pathogens, 2022 - journals.plos.org
Vorberg holds pending patent applications for “HERV inhibitors for use in treating tauopathies”:
“US Patent Application No. 17/640,119 based on PCT International application No. PCT/…

[HTML][HTML] Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

…, A Hebestreit, LB Andreas, IM Vorberg… - Nature …, 2021 - nature.com
Pathological aggregation of the protein tau into insoluble aggregates is a hallmark of
neurodegenerative diseases. The emergence of disease-specific tau aggregate structures termed …

[HTML][HTML] Acetylation discriminates disease-specific tau deposition

…, A Hebestreit, AI de Opakua, IM Vorberg… - Nature …, 2023 - nature.com
Pathogenic aggregation of the protein tau is a hallmark of Alzheimer’s disease and several
other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms …

[HTML][HTML] Reactivated endogenous retroviruses promote protein aggregate spreading

…, SF Lichtenthaler, P Denner, IM Vorberg - Nature …, 2023 - nature.com
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …

[HTML][HTML] Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

…, M Neumann, P Denner, IM Vorberg - Nature …, 2021 - nature.com
Protein aggregates associated with neurodegenerative diseases have the ability to transmit
to unaffected cells, thereby templating their own aberrant conformation onto soluble …

Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates

S Liu, A Hossinger, S Göbbels, IM Vorberg - Prion, 2017 - Taylor & Francis
Extracellular vesicles (EVs) are actively secreted, membrane-bound communication vehicles
that exchange biomolecules between cells. EVs also serve as dissemination vehicles for …

[HTML][HTML] Propagation and dissemination strategies of transmissible spongiform encephalopathy agents in mammalian cells

…, AS Hebestreit, A Hossinger, IM Vorberg - International Journal of …, 2022 - mdpi.com
Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases
that cause characteristic spongiform degeneration in the central nervous system. The …

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

…, X Wu, S Krebs, H Blum, E Kremmer, IM Vorberg… - Elife, 2021 - elifesciences.org
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in
the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, …

[HTML][HTML] Prion strains depend on different endocytic routes for productive infection

…, SA Priola, MH Groschup, HM Schätzl, IM Vorberg - Scientific reports, 2017 - nature.com
Prions are unconventional agents composed of misfolded prion protein that cause fatal
neurodegenerative diseases in mammals. Prion strains induce specific neuropathological …