[HTML][HTML] Dual inhibition of mTORC1/2 reduces migration of cholangiocarcinoma cells by regulation of matrixmetalloproteinases

K Joechle, H Jumaa, K Thriene… - Frontiers in Cell and …, 2022 - frontiersin.org
Cholangiocarcinoma (CCA) is a rare but highly aggressive tumor entity for which systemic
therapies only showed limited efficacy so far. As OSI-027—a dual kinase inhibitor targeting …

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes

H Jumaa, M Caganova, EJ McAllister… - Life Science …, 2020 - life-science-alliance.org
The major function of B lymphocytes is to sense antigens and to produce protective antibodies
after activation. This function requires the expression of a B-cell antigen receptor (BCR), …

Critical challenges of virtual learning environments (VLEs) and learning theories

…, MM Abdeldayem, HT Jumaa… - … for sustainability and …, 2022 - ieeexplore.ieee.org
the purpose of this study is to discuss the online learning circumstances and challenges that
emerged respectively after the influence of COVID-19. The main question of this study is, to …

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

KN Cosgun, H Jumaa, ME Robinson, KM Kistner, L Xu… - bioRxiv, 2023 - biorxiv.org
In most cell types, nuclear β-catenin functions as prominent oncogenic driver and pairs with
TCF7-family factors for transcriptional activation of MYC. Surprisingly, B-lymphoid …

GSK3β Inhibition Is a Unique Vulnerability in Lymphoid Malignancies

KN Cosgun, H Jumaa, ME Robinson, LN Chan, J Lee… - Blood, 2022 - ashpublications.org
Introduction Oncogenic activation of Wnt/β-catenin signaling is common throughout all types
of cancer. Analysis of β-catenin expression in a reverse phase protein array data set …

Accumulation of the GSK3 target protein β-catenin is lethal for B cell precursors and malignant B cells

H Jumaa, KM Kistner, C Setz, MM Taketo, H Jumaa… - bioRxiv, 2021 - biorxiv.org
Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed kinase involved in a myriad
of biological processes. Although GSK3 mediated phosphorylation has been shown to …

Knowledge Sharing Behaviour among Post-Graduate Students during the E-Learning Era

…, MYA Keir, HT Jumaa - … for Sustainability and …, 2022 - ieeexplore.ieee.org
This paper aims to develop a conceptual and theoretical research framework for students'
attitude towards knowledge sharing with their peers, and to determine the factors likely to …

β-catenin engages IKZF factors to control lymphopoiesis

KN Cosgun, H Jumaa, ME Robinson, L Xu… - The Journal of …, 2023 - journals.aai.org
β-catenin-signaling promotes proliferation and survival in epithelial, neuronal, and mesenchymal
lineages, but is dispensable for B-and T-cell development. β-catenin activation is a …

[PDF][PDF] Interpersonal Analysis of American Presidential Victory Speeches

HT Jumaa, A Al Hyali, MK Khalaf - iasj.net
The current study aims to investigate the discoursal function of modality and to reveal the
functions of modality represented by two victory speeches of Obama and Biden. Some issues …

Systemic Functional Linguistic Analysis of American Presidential Victory Speeches.

HT Jumaa Abed Al Hyali… - … Gami'at Al-Anbar Li-Lugat …, 2022 - search.ebscohost.com
The aim of the current study is to investigate the discoursal function of transitivity in the speeches
of Obama and Biden. Also, it is to reveal the functions of transitivity represented by two …