Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases to …

The full neutrophil heterogeneity and differentiation landscape remains incompletely characterized.
Here, we profiled >25,000 differentiating and mature mouse neutrophils using single-…

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in
macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD …

Neutrophil constitutive death is a critical cellular process for modulating neutrophil number
and function, and it plays an essential role in neutrophil homeostasis and the resolution of …

Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death
in neurological diseases. However, this endeavor has been hindered because of the lack of …

Protein kinase B/Akt possesses prosurvival and antiapoptotic activities and is involved in
growth factor-mediated neuronal protection. In this study we establish Akt deactivation as a …

Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of
innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on …

7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B
(TrkB) agonist. Our preliminary structural−activity relationship (SAR) study showed that the 7,…

In chemotaxing cells, localization of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P 3 ) to
the leading edge of the cell sets the direction and regulates the formation of pseudopods at …

Inositol phosphates are well-known signaling molecules, whereas the inositol
pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol …