[HTML][HTML] Precision drugging of the MAPK pathway in head and neck cancer
HL Ngan, CH Law, YCY Choi, JYS Chan… - NPJ genomic …, 2022 - nature.com
The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …
differentiation, and senescence. In human, germline defects of the pathway contribute to …
[HTML][HTML] Genomic landscapes of EBV-associated nasopharyngeal carcinoma vs. HPV-associated head and neck cancer
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human
papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct …
papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct …
[HTML][HTML] Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
…, MHN Law, PPY Law, ZWY Liu, HL Ngan… - Nature …, 2017 - nature.com
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …
[HTML][HTML] The cylindromatosis (CYLD) gene and head and neck tumorigenesis
KR Verhoeft, HL Ngan, VWY Lui - Cancers of the head & neck, 2016 - Springer
Germline CYLD mutation is associated with the development of a rare inheritable syndrome,
called the CYLD cutaneous syndrome. Patients with this syndrome are distinctly presented …
called the CYLD cutaneous syndrome. Patients with this syndrome are distinctly presented …
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
HL Ngan, Y Liu, AY Fong, PHY Poon… - Life science …, 2020 - life-science-alliance.org
MAPK pathway mutations affect one-fifth of head and neck squamous cell carcinoma (HNSCC).
Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient …
Unexpectedly, MAPK pathway aberrations are associated with remarkably long patient …
[HTML][HTML] Erlotinib sensitivity of MAPK1p.D321N mutation in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) lacks predictive biomarkers for drug
responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, …
responses. By targeted sequencing, we identified two MAPK1 mutations in recurrent HNSCC, …
[HTML][HTML] Comprehensive exome analysis of immunocompetent metastatic head and neck cancer models reveals patient relevant landscapes
H Li, HL Ngan, Y Liu, HHY Chan, PHY Poon… - Cancers, 2020 - mdpi.com
Simple Summary Head and neck cancer (HNC), once metastasized, is very difficult to treat
as there are limited therapy options. Animal models of such can be very useful for preclinical …
as there are limited therapy options. Animal models of such can be very useful for preclinical …
Precision drugging of the MAPK pathway in head and neck cancer
N Hoi-Lam, L Chun-Ho, CYC Yan… - NPJ Genomic …, 2022 - search.proquest.com
The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …
differentiation, and senescence. In human, germline defects of the pathway contribute to …
RAC1 genomic aberrations as predictive biomarkers for head and neck squamous cell carcinoma (HNSCC)
HL Ngan, Y Liu, PHY Poon, VWY Lui - Cancer Research, 2019 - AACR
RAC1 is a small GTPase with known oncogenicity. Mutations of RAC1 are highly relevant to
melanoma. Yet, little is known about RAC1 aberrations in other human cancers, including …
melanoma. Yet, little is known about RAC1 aberrations in other human cancers, including …
Study of CCCTC-binding factor (CTCF) genetic aberrations and dysregulation in head and neck squamous cell carcinoma (HNSCC)
SM Chan, HL Ngan, Y Liu, W Piao, CW Lau, JYK Chan… - Cancer Research, 2019 - AACR
CCCTC-binding Factor (CTCF) is a DNA-binding protein that acts as a global genome
organizer in higher eukaryotes. CTCF folds the genome into spatial domains that is crucial for …
organizer in higher eukaryotes. CTCF folds the genome into spatial domains that is crucial for …