DNA methylation plays a key role in the silencing of numerous cancer-related genes, thereby
affecting a number of vital cellular processes, including the cell cycle checkpoint, apoptosis…

Recent advances in genome and transcriptome analysis have enabled identification of
numerous members of a new class of noncoding RNA, long noncoding RNA (lncRNA). lncRNAs …

MicroRNAs (miRNAs) play pivotal roles in numerous biological processes, and their
dysregulation is a common feature of human cancer. Thanks to recent advances in the analysis of …

Aberrant WNT pathway signaling is an early progression event in 90% of colorectal cancers
1 . It occurs through mutations mainly of APC and less often of CTNNB1 (encoding β-catenin…

Aberrant hypermethylation of gene promoters is a major mechanism associated with
inactivation of tumor-suppressor genes in cancer. We previously showed this transcriptional …

Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies
have shown that, in cancer, expression of some miRNAs cells is silenced in association …

Aberrant methylation of 5′ CpG islands is thought to play an important role in the
inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is …

Large intergenic noncoding RNAs (lincRNA) have been less studied than miRNAs in cancer,
although both offer considerable theranostic potential. In this study, we identified frequent …

Fusobacterium species are part of the gut microbiome in humans. Recent studies have
identified overrepresentation of Fusobacterium in colorectal cancer tissues, but it is not yet clear …

We have developed a transcriptome-wide approach to identify genes affected by promoter
CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By …