Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with …

…, H Mugishima, K Sugita, H Yabe… - Blood, The Journal …, 2000 - ashpublications.org
A prospective multicenter trial of 119 children 1 to 18 years of age with newly diagnosed
aplastic anemia (AA) was conducted, comparing treatment using antithymocyte globulin (ATG), …

[PDF][PDF] Risk-stratified therapy and the intensive use of cytarabine improves the outcome in childhood acute myeloid leukemia: the AML99 trial from the Japanese …

…, K Tabuchi, H Kigasawa, M Tsuchida, H Yabe… - Journal of Clinical …, 2009 - jplsg.jp
… Ichiro Tsukimoto, Akio Tawa, Keizo Horibe, Ken Tabuchi, Hisato Kigasawa, Masahiro
Tsuchida, Hiromasa Yabe, Hideki Nakayama, Kazuko Kudo, Ryoji Kobayashi, Kazuko …

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

A Hira, H Yabe, K Yoshida, Y Okuno… - Blood, The Journal …, 2013 - ashpublications.org
Fanconi anemia (FA) is a severe hereditary disorder with defective DNA damage response
and repair. It is characterized by phenotypes including progressive bone marrow failure (BMF…

[PDF][PDF] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans

…, M Kato, S Miyano, E Ito, S Kojima, H Yabe, M Yabe… - Molecular cell, 2020 - cell.com
Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, …

Long-term efficacy of hematopoietic stem cell transplantation on brain involvement in patients with mucopolysaccharidosis type II: a nationwide survey in Japan

…, T Otomo, T Ohashi, M Ishige-Wada, H Yabe… - Molecular genetics and …, 2012 - Elsevier
… Okuyama b , Yasuyuki Suzuki c , Norio Sakai d , Hiromitsu Takakura e f , Tomo Sawada m ,
Toju Tanaka b , Takanobu Otomo d , Toya Ohashi g , Mika Ishige-Wada h , Hiromasa Yabe e …

[HTML][HTML] Hematopoietic stem cell transplantation for mucopolysaccharidoses: past, present, and future

…, M Stapleton, J Wang, J Chen, R Wynn, H Yabe… - Biology of Blood and …, 2019 - Elsevier
Allogenic hematopoietic stem cell transplantation (HSCT) has proven to be a viable treatment
option for a selected group of patients with mucopolysaccharidoses (MPS), including those …

[PDF][PDF] Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia

…, S Ogawa, M Takata, H Yabe, M Yabe - The American Journal of …, 2015 - cell.com
Fanconi anemia (FA) is a rare genetic disorder characterized by genome instability, increased
cancer susceptibility, progressive bone marrow failure (BMF), and various developmental …

[HTML][HTML] First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy

N Yoshida, R Kobayashi, H Yabe, Y Kosaka… - …, 2014 - ncbi.nlm.nih.gov
The current treatment approach for severe aplastic anemia in children is based on studies
performed in the 1980s, and updated evidence is required. We retrospectively compared the …

Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for …

…, H Ayukawa, T Kaneko, H Yabe… - Blood, The Journal …, 2008 - ashpublications.org
We conducted a prospective multicenter study to compare the efficacy of repeated
immunosuppressive therapy (IST) with stem-cell transplantation (SCT) from an alternative donor in …

Therapies for the bone in mucopolysaccharidoses

…, CJ Alméciga-Díaz, AM Montaño, H Yabe… - Molecular genetics and …, 2015 - Elsevier
Patients with mucopolysaccharidoses (MPS) have accumulation of glycosaminoglycans in
multiple tissues which may cause coarse facial features, mental retardation, recurrent ear and …