Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

T Mizushima, H Yagi, E Takemoto… - Genes to …, 2011 - Wiley Online Library
Removal of the fucose residue from the N‐glycans of the Fc portion of immunoglobulin G (IgG)
results in a dramatic enhancement of antibody‐dependent cellular cytotoxicity (ADCC) …

Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy

Y Yamaguchi, M Nishimura, M Nagano, H Yagi… - … et Biophysica Acta (BBA …, 2006 - Elsevier
The Fc portion of immunoglobulin G (IgG) expresses the biantennary complex type
oligosaccharides at Asn297 of the C H 2 domain of each heavy chain with microheterogeneities …

Edible bird's nest extract inhibits influenza virus infection

CT Guo, T Takahashi, W Bukawa, N Takahashi, H Yagi… - Antiviral research, 2006 - Elsevier
Edible bird's nest (EBN) is the nest of the swift that is made from its saliva. Although EBN
has been widely used for enhancing immunocompetence, its antiviral efficacy has not been …

[HTML][HTML] Comparison of methods for profiling O-glycosylation: human proteome organisation human disease glycomics/proteome initiative multi-institutional study of …

…, MB Renfrow, M Tajiri, KA Thomsson, H Yagi… - Molecular & Cellular …, 2010 - ASBMB
The Human Proteome Organisation Human Disease Glycomics/Proteome Initiative recently
coordinated a multi-institutional study that evaluated methodologies that are widely used for …

[HTML][HTML] NIST interlaboratory study on glycosylation analysis of monoclonal antibodies: comparison of results from diverse analytical methods

…, R Jones, CJM Stroop, K Kato, H Yagi… - Molecular & Cellular …, 2020 - ASBMB
Glycosylation is a topic of intense current interest in the development of biopharmaceuticals
because it is related to drug safety and efficacy. This work describes results of an …

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

…, S Varshney, M Ogawa, Y Sakaidani, H Yagi… - elife, 2017 - elifesciences.org
10.7554/eLife.24419.001 The glycosyltransferase EOGT transfers O-GlcNAc to a consensus
site in epidermal growth factor-like (EGF) repeats of a limited number of secreted and …

The quail and chicken intestine have sialyl-galactose sugar chains responsible for the binding of influenza A viruses to human type receptors

CT Guo, N Takahashi, H Yagi, K Kato… - …, 2007 - academic.oup.com
The receptor specificity of influenza viruses is one factor that allows avian influenza viruses
to cross the species barrier. The recent transmissions of avian H5N1 and H9N2 influenza …

[HTML][HTML] Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa

Y Sakae, T Satoh, H Yagi, S Yanaka, T Yamaguchi… - Scientific reports, 2017 - nature.com
Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between
the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-…

IgEb immune complexes activate macrophages through FcγRIV binding

…, WD Fine, S Nakamura, K Shimizu, H Yagi… - Nature …, 2007 - nature.com
Because functional analysis of Fc receptors (FcRs) relies heavily on mouse models, the
identification of another Fcγ receptor is particularly noteworthy. We demonstrate that FcγRIV, …

The expression of sialylated high-antennary N-glycans in edible bird's nest

H Yagi, N Yasukawa, SY Yu, CT Guo, N Takahashi… - Carbohydrate …, 2008 - Elsevier
Edible bird’s nest (EBN) is the nest made from the saliva of Collocalia swift. Recently, we
have found that EBN extract could strongly inhibit infection of influenza viruses in a host-range-…