Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

In the past few years our understanding of nuclear receptor action has dramatically
improved as a result of the elucidation of the crystal structures of the empty (apo) ligand-binding …

The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals
a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric units…

The 2.0-Å crystal structure of the ligand-binding domain (LBD) of the human retinoic acid
receptor (RAR)-γ bound to all-trans retinoic acid reveals the ligand-binding interactions and …

Nuclear receptors (NRs) act as ligand‐inducible transcription factors which regulate the
expression of target genes upon binding to cognate response elements. The ligand‐dependent …

The ability of nuclear receptors (NRs) to activate transcription of target genes requires the
binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the …

Retinoids have a reputation for being both detrimental and beneficial: they are teratogens,
but they also have tumour-suppressive capacity. Cell biology and genetics have significantly …

Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-)malignant cells 1 , 2 . Key signalling components of the senescence …

Cell death is essential for a plethora of physiological processes, and its deregulation
characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its …