User profiles for Hinrich Gronemeyer
Hinrich GronemeyerResearch Director (DRE) at the IGBMC Strasbourg-Illkirch, France Verified email at igbmc.fr Cited by 45856 |
[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
Principles for modulation of the nuclear receptor superfamily
Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …
The nuclear receptor ligand-binding domain: structure and function
D Moras, H Gronemeyer - Current opinion in cell biology, 1998 - Elsevier
In the past few years our understanding of nuclear receptor action has dramatically
improved as a result of the elucidation of the crystal structures of the empty (apo) ligand-binding …
improved as a result of the elucidation of the crystal structures of the empty (apo) ligand-binding …
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
W Bourguet, M Ruff, P Chambon, H Gronemeyer… - Nature, 1995 - nature.com
The crystal structure of the human retinoid-X receptor RXR-α ligand-binding domain reveals
a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric units…
a previously undiscovered fold of an antiparallel α-helical sandwich, packed as dimeric units…
Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
…, N Rochel, M Ruff, V Vivat, P Chambon, H Gronemeyer… - Nature, 1995 - nature.com
The 2.0-Å crystal structure of the ligand-binding domain (LBD) of the human retinoic acid
receptor (RAR)-γ bound to all-trans retinoic acid reveals the ligand-binding interactions and …
receptor (RAR)-γ bound to all-trans retinoic acid reveals the ligand-binding interactions and …
TIF2, a 160 kDa transcriptional mediator for the ligand‐dependent activation function AF‐2 of nuclear receptors.
…, C Zechel, P Chambon, H Gronemeyer - The EMBO …, 1996 - embopress.org
Nuclear receptors (NRs) act as ligand‐inducible transcription factors which regulate the
expression of target genes upon binding to cognate response elements. The ligand‐dependent …
expression of target genes upon binding to cognate response elements. The ligand‐dependent …
A canonical structure for the ligand-binding domain of nuclear receptors
…, V Vivat, P Chambon, D Moras, H Gronemeyer - Nature structural …, 1996 - nature.com
The ability of nuclear receptors (NRs) to activate transcription of target genes requires the
binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the …
binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the …
The promise of retinoids to fight against cancer
L Altucci, H Gronemeyer - Nature Reviews Cancer, 2001 - nature.com
Retinoids have a reputation for being both detrimental and beneficial: they are teratogens,
but they also have tumour-suppressive capacity. Cell biology and genetics have significantly …
but they also have tumour-suppressive capacity. Cell biology and genetics have significantly …
Senescence-associated reprogramming promotes cancer stemness
Cellular senescence is a stress-responsive cell-cycle arrest program that terminates the
further expansion of (pre-)malignant cells 1 , 2 . Key signalling components of the senescence …
further expansion of (pre-)malignant cells 1 , 2 . Key signalling components of the senescence …
[HTML][HTML] Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Cell death is essential for a plethora of physiological processes, and its deregulation
characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its …
characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its …