Identification of Holliday junction resolvases from humans and yeast
Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous
recombination and DNA repair, and their resolution is necessary for proper chromosome …
recombination and DNA repair, and their resolution is necessary for proper chromosome …
[PDF][PDF] CDK substrate phosphorylation and ordering the cell cycle
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …
complexes. However, it has been suggested that changes in the total level of CDK kinase …
[HTML][HTML] Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study
…, L Holt, H Ahmod, R Stone, C Gomes, HR Flynn… - Nature Cancer, 2021 - nature.com
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the
prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. …
prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. …
[HTML][HTML] The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function
…, YH Lin, A Gül, N Soni, C Hastings, HR Flynn… - Nature …, 2023 - nature.com
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis,
linking external stimuli to transcriptional co-activation of genes involved in adaptive and …
linking external stimuli to transcriptional co-activation of genes involved in adaptive and …
[PDF][PDF] A structure-based mechanism for DNA entry into the cohesin ring
…, P Eickhoff, JS Sousa, J Locke, A Nans, HR Flynn… - Molecular cell, 2020 - cell.com
Despite key roles in sister chromatid cohesion and chromosome organization, the
mechanism by which cohesin rings are loaded onto DNA is still unknown. Here we combine …
mechanism by which cohesin rings are loaded onto DNA is still unknown. Here we combine …
Global Identification of Multiple Substrates for Plasmodium falciparum SUB1, an Essential Malarial Processing Protease
NC Silmon de Monerri, HR Flynn… - Infection and …, 2011 - Am Soc Microbiol
The protozoan pathogen responsible for the most severe form of human malaria,
Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound …
Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound …
Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity
…, F Miralles, R Pawlowski, J Diring, HR Flynn… - Elife, 2016 - elifesciences.org
10.7554/eLife.15460.001 The myocardin-related transcription factors (MRTF-A and MRTF-B)
regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind …
regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind …
[HTML][HTML] Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
…, J de Folter, SK Aulakh, Z Wang, HR Flynn… - Nature Biomedical …, 2023 - nature.com
Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …
CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle
The protection of telomere ends by the shelterin complex prevents DNA damage signalling
and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-…
and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-…
[PDF][PDF] Polε instability drives replication stress, abnormal development, and tumorigenesis
…, E Nye, K Metcalfe, SM O'Connell, G Stamp, HR Flynn… - Molecular cell, 2018 - cell.com
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase
in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity …
in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity …