Identification of Holliday junction resolvases from humans and yeast

SCY Ip, U Rass, MG Blanco, HR Flynn, JM Skehel… - Nature, 2008 - nature.com
Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous
recombination and DNA repair, and their resolution is necessary for proper chromosome …

[PDF][PDF] CDK substrate phosphorylation and ordering the cell cycle

MP Swaffer, AW Jones, HR Flynn, AP Snijders, P Nurse - Cell, 2016 - cell.com
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …

[HTML][HTML] Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study

…, L Holt, H Ahmod, R Stone, C Gomes, HR Flynn… - Nature Cancer, 2021 - nature.com
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the
prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. …

[HTML][HTML] The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function

…, YH Lin, A Gül, N Soni, C Hastings, HR Flynn… - Nature …, 2023 - nature.com
PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis,
linking external stimuli to transcriptional co-activation of genes involved in adaptive and …

[PDF][PDF] A structure-based mechanism for DNA entry into the cohesin ring

…, P Eickhoff, JS Sousa, J Locke, A Nans, HR Flynn… - Molecular cell, 2020 - cell.com
Despite key roles in sister chromatid cohesion and chromosome organization, the
mechanism by which cohesin rings are loaded onto DNA is still unknown. Here we combine …

Global Identification of Multiple Substrates for Plasmodium falciparum SUB1, an Essential Malarial Processing Protease

NC Silmon de Monerri, HR Flynn… - Infection and …, 2011 - Am Soc Microbiol
The protozoan pathogen responsible for the most severe form of human malaria,
Plasmodium falciparum, replicates asexually in erythrocytes within a membrane-bound …

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

…, F Miralles, R Pawlowski, J Diring, HR Flynn… - Elife, 2016 - elifesciences.org
10.7554/eLife.15460.001 The myocardin-related transcription factors (MRTF-A and MRTF-B)
regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind …

[HTML][HTML] Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics

…, J de Folter, SK Aulakh, Z Wang, HR Flynn… - Nature Biomedical …, 2023 - nature.com
Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

…, D Van Ly, P Margalef, V Borel, XF Zheng, HR Flynn… - Nature, 2019 - nature.com
The protection of telomere ends by the shelterin complex prevents DNA damage signalling
and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-…

[PDF][PDF] Polε instability drives replication stress, abnormal development, and tumorigenesis

…, E Nye, K Metcalfe, SM O'Connell, G Stamp, HR Flynn… - Molecular cell, 2018 - cell.com
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase
in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity …