The mechanisms that regulate the acidification of intracellular compartments are key to host
defense against pathogens. In this paper, we demonstrate that Abl tyrosine kinase, a master …

Control of tuberculosis worldwide depends on our understanding of human immune
mechanisms, which combat the infection. Acquired T cell responses are critical for host defense …

The incidence of tuberculosis is increased during treatment of autoimmune diseases with
anti-TNF antibodies. This is a significant clinical complication, but also provides a unique …

A key target of many intracellular pathogens is the macrophage. Although macrophages
can generate antimicrobial activity, neutrophils have been shown to have a key role in host …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Alterations of cellular metabolism represent a hallmark of cancer. Numerous metabolic
changes are required for malignant transformation, and they render malignant cells more prone …

As substantial constituents of the multiple myeloma (MM) microenvironment, pro-inflammatory
macrophages have emerged as key promoters of disease progression, bone destruction, …

Infiltration by macrophages represents a characteristic morphological hallmark in high-grade
lymphatic malignancies such as Burkitt’s lymphoma (BL). Although macrophages can, in …

Generalized pustular psoriasis (GPP) is a severe multi-systemic inflammatory disease
characterized by neutrophilic pustulosis and triggered by pro-inflammatory IL-36 cytokines in skin. …

T-cell-based therapies represent a promising strategy for cancer treatment. In this context,
cytokines are discussed as a bona fide instrument for fine-tuning T-cell biology. One promising …