Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
10.7554/eLife.16351.001 The FDA approved drug rapamycin increases lifespan in rodents
and delays age-related dysfunction in rodents and humans. Nevertheless, important …
and delays age-related dysfunction in rodents and humans. Nevertheless, important …
PKC downregulation upon rapamycin treatment attenuates mitochondrial disease
…, TK Ito, AS Valente, J Han, SW Entwisle, HZ Huang… - Nature …, 2020 - nature.com
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial
function. Mechanistic target of rapamycin (mTOR) inhibition with rapamycin attenuates disease …
function. Mechanistic target of rapamycin (mTOR) inhibition with rapamycin attenuates disease …
Chromosome length and gene density contribute to micronuclear membrane stability
AE Mammel, HZ Huang, AL Gunn… - Life Science …, 2022 - life-science-alliance.org
Micronuclei are derived from missegregated chromosomes and frequently lose membrane
integrity, leading to DNA damage, innate immune activation, and metastatic signaling. Here, …
integrity, leading to DNA damage, innate immune activation, and metastatic signaling. Here, …
[HTML][HTML] Hepatic S6K1 partially regulates lifespan of mice with mitochondrial complex I deficiency
… Ito 1,2,3 * Chenhao Lu Chenhao Lu 1 Jacob Khan Jacob Khan 1 Quy Nguyen Quy Nguyen
1 Heather Z. Huang Heather Z. Huang 1 Dayae Kim Dayae Kim 1 James Phillips James …
1 Heather Z. Huang Heather Z. Huang 1 Dayae Kim Dayae Kim 1 James Phillips James …
Machine vision reveals micronucleus rupture as a potential driver of the transcriptomic response to aneuploidy
L DiPeso, S Pendyala, HZ Huang, DM Fowler… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Micronuclei are aberrant nuclear compartments that trap a portion of a cell's chromatin in a
distinct organelle separate from the nucleus and are drivers of inflammation, DNA damage, …
distinct organelle separate from the nucleus and are drivers of inflammation, DNA damage, …
Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
…, AS Grillo, AS Valente, J Han, S Entwisle, HZ Huang… - bioRxiv, 2019 - biorxiv.org
Leigh syndrome is a fatal neurometabolic disorder caused by defects in mitochondrial
function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of …
function. mTOR inhibition with rapamycin attenuates disease progression in a mouse model of …
[HTML][HTML] Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens
MTG Holden, Z Heather, R Paillot, KF Steward… - PLoS …, 2009 - journals.plos.org
The continued evolution of bacterial pathogens has major implications for both human and
animal disease, but the exchange of genetic material between host-restricted pathogens is …
animal disease, but the exchange of genetic material between host-restricted pathogens is …
[PDF][PDF] Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction
MTG Holden, Z Heather, R Paillot, KF Steward, K Webb - 2009 - academia.edu
The continued evolution of bacterial pathogens has major implications for both human and
animal disease, but the exchange of genetic material between host-restricted pathogens is …
animal disease, but the exchange of genetic material between host-restricted pathogens is …
Interfacial water structure associated with phospholipid membranes studied by phase-sensitive vibrational sum frequency generation spectroscopy
X Chen, W Hua, Z Huang, HC Allen - Journal of the American …, 2010 - ACS Publications
Phase-sensitive vibrational sum frequency generation is employed to investigate the water
structure at phospholipid/water interfaces. Interfacial water molecules are oriented …
structure at phospholipid/water interfaces. Interfacial water molecules are oriented …
Binding of Mg2+ and Ca2+ to Palmitic Acid and Deprotonation of the COOH Headgroup Studied by Vibrational Sum Frequency Generation Spectroscopy
CY Tang, Z Huang, HC Allen - The Journal of Physical Chemistry …, 2010 - ACS Publications
… Zishuai Huang, Wei Hua, Dominique Verreault, and Heather C. Allen . Influence of Salt …
Casper, Heather C. Allen. Effect of cation enrichment on dipalmitoylphosphatidylcholine (DPPC) …
Casper, Heather C. Allen. Effect of cation enrichment on dipalmitoylphosphatidylcholine (DPPC) …