Mitochondrial fission is essential for the degradation of damaged mitochondria. It is currently
unknown how the dynamin-related protein 1 (DRP1)–associated fission machinery is …

Recent interest in astrocyte activation states has raised the fundamental question of how
these cells, normally essential for synapse and neuronal maintenance, become pathogenic. …

… Correspondence concerning this article should be addressed to Heather L. Smith,
Human Development Counseling, Department of Human and Organizational Development, …

Activation of the unfolded protein response is emerging as a common theme in protein-misfolding
neurodegenerative diseases, with relevant markers observed in patient tissue and …

Tonic receptors convey stimulus duration and intensity and are implicated in homeostatic
control. However, how tonic homeostatic signals are generated and how they reconfigure …

… Our lab has confirmed the pathogenicity of the HSJ1 Y5C mutation (Heather Smith,
unpublished observations). All three mutations identified thus far lead to a loss of HSJ1 function, …

10.7554/eLife.15275.001 Mitochondria support synaptic transmission through production of
ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, …

Double-stranded (ds) RNA, a common product of viral infection, can induce transcription of
many cellular genes, including the 561 gene that encodes P56, a regulator of protein …

Advances in the understanding of the molecular biology of central nervous system (CNS)
tumors prompted a new World Health Organization (WHO) classification scheme in 2021, only …

Double-stranded (ds) RNA induces transcription of the 561 gene by activating IFN regulatory
factor (IRF) transcription factors, whereas similar induction of the IFN-β gene is thought to …