Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …

In fluorescence‐based flow cytometry, cellular viability is determined with membrane‐impermeable
fluorescent reagents that specifically enter and label plasma membrane‐…

An individual malignant tumor is composed of a heterogeneous collection of single cells
with distinct molecular and phenotypic features, a phenomenon termed intratumoral …

Millions of seahorses a year are traded internationally, with many eventually sold at retail
shops as curios, as aquarium pets, and especially for use in traditional medicine. The entire …

TNFα-related apoptosis-inducing ligand (TRAIL), specifically initiates programmed cell
death, but often fails to eradicate all cells, making it an ineffective therapy for cancer. This …

Nongenetic resistance has recently been described as a major impediment to effective cancer
therapy. Nongenetic resistance is challenging to study since it occurs nonuniformly, even …

High-dimensional cytometry has ushered in a new era of single-cell analysis. High-end flow
cytometers are now capable of 15-parameter analysis and the mass cytometer is routinely …

Chemotherapeutic drug resistance is one of the critical impediments to successful malignant
tumor treatment in humans. Conventional thinking is that a subset of tumor cells variably …

Abstract 3160 While oncogene addiction is a well-documented phenomenon, the molecular
mechanisms by which oncogene withdrawal triggers cell death are poorly understood. …

Acute myeloid leukemia (AML) can present with multiple concurrent subclones at diagnosis.
Subclone-specific mutations may confer resistance to molecular-targeted drugs through loss …