Spatial organization of cells and their appendages is controlled by the planar cell polarity
pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates …

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease, caused by
mutations of at least nine different genes. Several extrarenal manifestations characterize this …

Due to the ubiquity of environmental micro- and nanoplastics (MNPs), inhalation and ingestion
by humans is very likely, but human health effects remain largely unknown. The NLRP3 …

EBF1 and PAX5 mutations are associated with the development of B progenitor acute
lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving …

Genome engineering-induced cleavage sites can be resolved by non-homologous end joining
(NHEJ) or homology-directed repair (HDR). Identifying genetically modified clones at the …

The NLRP3 inflammasome plays an important role in intestinal homeostasis as well as
inflammation. However, in vivo studies investigating the role of the NLRP3 inflammasome in …

In the last decade, transcription activator-like effector nucleases and CRISPR-based genome
engineering have revolutionized our approach to biology. Because of their high efficiency …

Nephronophthisis (NPH) is a heterogenetic autosomal recessive disorder associated with
kidney cysts and multiple extrarenal manifestations. The disease-associated gene products (…

Genomic mutations are the driving force of biological diversity but they are also the cause of
a plethora of human diseases ranging from heritable disorders to neurological pathologies …

The establishment of cell fates involves alterations of transcription factor repertoires and
repurposing of transcription factors by post-translational modifications. In embryonic stem cells (…