Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS
(complex of proteins associated with Set1) family from Saccharomyces cerevisiae to …

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …

Epigenetic modifications of chromatin play an important role in the regulation of gene expression.
KMT4/Dot1 is a conserved histone methyltransferase capable of methylating chromatin …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of its …

Numerous studies focus on the tumor suppressor p53 as a protector of genomic stability,
mediator of cell cycle arrest and apoptosis, and target of mutation in 50% of all human cancers. …

Methylation of histone H3 lysine 4 (H3K4) in Saccharomyces cerevisiae is implemented by
Set1/COMPASS, which was originally purified based on the similarity of yeast Set1 to human …

Why certain point mutations in a general transcription factor are associated with specific
forms of cancer has been a major question in cancer biology. Enhancers are DNA regulatory …

Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved feature of
enhancer chromatin catalyzed by the COMPASS-like methyltransferase family, which …

Histone H3 lysine 27 -to-methionine (H3K27M) gain-of-function mutations occur in highly
aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic …

Appropriate cell-cell signaling is crucial for proper tissue homeostasis. Protein sorting of cell
surface receptors at the early endosome is important for both the delivery of the signal and …