T lymphocytes reactive with the product of the Mls a -allele of the minor lymphocyte stimulating
(Mls) locus use a predominant T-cell receptor β-chain variable gene segment (V β6 ). …

The class II transactivator (CIITA) has been referred to as the "master control factor" for the
expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of …

Recirculating virgin CD4 + T cells spend their life migrating between the T zones of
secondary lymphoid tissues where they screen the surface of interdigitating dendritic cells. T‐cell …

Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses,
including cell growth, differentiation, and even death. Here we describe a novel member of …

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its
cellular source in the periphery remains poorly defined. Here we report a critical function for …

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These
cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-…

Experimental allergic encephalomyelitis(EAE) is an induced autoimmune disease mediated
by CD4+ T lymphocytes. Analysis of T cell receptors of myelin basic protein-specific …

Mucocutaneous leishmaniasis is caused by infections with intracellular parasites of the
Leishmania Viannia subgenus, including Leishmania guyanensis. The pathology develops after …

B cell activating factor of the tumor necrosis factor (TNF) family (BAFF) and a proliferation-inducing
ligand (APRIL) are closely related ligands within the TNF superfamily that play …

Mice lacking in CD8 were generated from homologous recombination in embryonal stem
cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)…