User profiles for Hai-Bin Ruan

Hai-Bin Ruan

University of Minnesota
Verified email at umn.edu
Cited by 4553

Cracking the O-GlcNAc code in metabolism

HB Ruan, JP Singh, MD Li, J Wu, X Yang - Trends in Endocrinology & …, 2013 - cell.com
Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-N-acetylglucosamine
(O-GlcNAc) moieties. This sugar modification regulates fundamental …

[HTML][HTML] Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination

HB Ruan, Y Nie, X Yang - Molecular & Cellular Proteomics, 2013 - ASBMB
The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine
(O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, …

[PDF][PDF] Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

…, A Abudukadier, MS Han, XM Zhang, HB Ruan… - Cell, 2015 - cell.com
Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which this …

Ketone bodies as epigenetic modifiers

HB Ruan, PA Crawford - Current Opinion in Clinical Nutrition & …, 2018 - journals.lww.com
Direct regulation of gene expression may occur in-vivo via through ketone body-mediated
histone modifications during adherence to low-carbohydrate diets, fasting ketosis, exogenous …

[PDF][PDF] O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability

HB Ruan, X Han, MD Li, JP Singh, K Qian… - Cell metabolism, 2012 - cell.com
A major cause of hyperglycemia in diabetic patients is inappropriate hepatic gluconeogenesis.
PGC-1α is a master regulator of gluconeogenesis, and its activity is controlled by various …

[PDF][PDF] The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis

…, H Chim, MJ Jurczak, JP Camporez, HB Ruan… - Molecular cell, 2012 - cell.com
Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can
also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling/…

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

S Diano, ZW Liu, JK Jeong, MO Dietrich, HB Ruan… - Nature medicine, 2011 - nature.com
Previous studies have proposed roles for hypothalamic reactive oxygen species (ROS) in
the modulation of circuit activity of the melanocortin system 1 , 2 . Here we show that …

[PDF][PDF] O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat

HB Ruan, MO Dietrich, ZW Liu, MR Zimmer, MD Li… - Cell, 2014 - cell.com
Induction of beige cells causes the browning of white fat and improves energy metabolism.
However, the central mechanism that controls adipose tissue browning and its physiological …

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression

…, N Tolliday, JP Camporez, H Chim, JH Lim, HB Ruan… - Nature, 2014 - nature.com
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining
glucose homeostasis 1 , 2 , 3 ; dysregulation of this axis causes diabetes 2 , 4 . PGC-1α (…

[PDF][PDF] O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination

MD Li, HB Ruan, ME Hughes, JS Lee, JP Singh… - Cell metabolism, 2013 - cell.com
Circadian clocks are coupled to metabolic oscillations through nutrient-sensing pathways.
Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein modification …