User profiles for Hai-Bin Ruan
Hai-Bin RuanUniversity of Minnesota Verified email at umn.edu Cited by 4553 |
Cracking the O-GlcNAc code in metabolism
Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-N-acetylglucosamine
(O-GlcNAc) moieties. This sugar modification regulates fundamental …
(O-GlcNAc) moieties. This sugar modification regulates fundamental …
[HTML][HTML] Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination
The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine
(O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, …
(O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, …
[PDF][PDF] Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
…, A Abudukadier, MS Han, XM Zhang, HB Ruan… - Cell, 2015 - cell.com
Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which this …
role in the pathogenesis of type 2 diabetes (T2D), yet the molecular mechanism by which this …
Ketone bodies as epigenetic modifiers
HB Ruan, PA Crawford - Current Opinion in Clinical Nutrition & …, 2018 - journals.lww.com
Direct regulation of gene expression may occur in-vivo via through ketone body-mediated
histone modifications during adherence to low-carbohydrate diets, fasting ketosis, exogenous …
histone modifications during adherence to low-carbohydrate diets, fasting ketosis, exogenous …
[PDF][PDF] O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability
A major cause of hyperglycemia in diabetic patients is inappropriate hepatic gluconeogenesis.
PGC-1α is a master regulator of gluconeogenesis, and its activity is controlled by various …
PGC-1α is a master regulator of gluconeogenesis, and its activity is controlled by various …
[PDF][PDF] The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis
…, H Chim, MJ Jurczak, JP Camporez, HB Ruan… - Molecular cell, 2012 - cell.com
Hepatic glucose production (HGP) maintains blood glucose levels during fasting but can
also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling/…
also exacerbate diabetic hyperglycemia. HGP is dynamically controlled by a signaling/…
Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
Previous studies have proposed roles for hypothalamic reactive oxygen species (ROS) in
the modulation of circuit activity of the melanocortin system 1 , 2 . Here we show that …
the modulation of circuit activity of the melanocortin system 1 , 2 . Here we show that …
[PDF][PDF] O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat
Induction of beige cells causes the browning of white fat and improves energy metabolism.
However, the central mechanism that controls adipose tissue browning and its physiological …
However, the central mechanism that controls adipose tissue browning and its physiological …
Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression
…, N Tolliday, JP Camporez, H Chim, JH Lim, HB Ruan… - Nature, 2014 - nature.com
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining
glucose homeostasis 1 , 2 , 3 ; dysregulation of this axis causes diabetes 2 , 4 . PGC-1α (…
glucose homeostasis 1 , 2 , 3 ; dysregulation of this axis causes diabetes 2 , 4 . PGC-1α (…
[PDF][PDF] O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination
Circadian clocks are coupled to metabolic oscillations through nutrient-sensing pathways.
Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein modification …
Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein modification …