User profiles for H. Walden
 | Helen WaldenUniversity of Glasgow Verified email at glasgow.ac.uk Cited by 6668 |
Ubiquitin signalling in DNA replication and repair
Post-translational modification by ubiquitin is best known for its role in targeting its substrates
for regulated degradation. However, non-proteolytic functions of the ubiquitin system, often …
for regulated degradation. However, non-proteolytic functions of the ubiquitin system, often …
RBR E3 ubiquitin ligases: new structures, new insights, new questions
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING
finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. …
finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes. …
The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder
… We are grateful to members of the Walden and Deans labs for critical comments on the
manuscript. This research was supported by Cancer Research UK and grants from the National …
manuscript. This research was supported by Cancer Research UK and grants from the National …
Measurements of wind-wave growth and swell decay during the Joint North Sea Wave Project (JONSWAP).
…, DJ Olbers, K Richter, W Sell, H Walden - … Zeitschrift, Reihe A, 1973 - pure.mpg.de
Wavo spectra were measured along a profile extending 160 km into the North Sea westward
from Sylt for a period of ten weeks in 1969. Currents, tides, air-sea temperature differences …
from Sylt for a period of ten weeks in 1969. Currents, tides, air-sea temperature differences …
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited
Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect …
Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect …
[PDF][PDF] Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction
domain such as MATH recruits substrates for ubiquitination. Here, we present …
domain such as MATH recruits substrates for ubiquitination. Here, we present …
[HTML][HTML] The CCP4 suite: integrative software for macromolecular crystallography
…, A Vagin, S Velankar, M Vollmar, H Walden… - … Section D: Structural …, 2023 - scripts.iucr.org
The Collaborative Computational Project No. 4 (CCP4) is a UK-led international collective
with a mission to develop, test, distribute and promote software for macromolecular …
with a mission to develop, test, distribute and promote software for macromolecular …
[PDF][PDF] Types of ubiquitin ligases
FE Morreale, H Walden - Cell, 2016 - cell.com
Ubiquitination is a post-translational modification of proteins involved in a variety of cellular
processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-…
processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-…
Autoregulation of Parkin activity through its ubiquitin‐like domain
… After transfections, cells were maintained for 48 h including a 10‐h treatment with 10 μM
proteasome inhibitor MG132 (Calbiochem) where indicated. Cells were lysed and sonicated in …
proteasome inhibitor MG132 (Calbiochem) where indicated. Cells were lysed and sonicated in …
[PDF][PDF] The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden, MS Podgorski, DT Huang, DW Miller… - Molecular cell, 2003 - cell.com
E1 enzymes initiate ubiquitin-like protein (ubl) transfer cascades by catalyzing adenylation
of the ubl's C terminus. An E1's selectivity for its cognate ubl is essential because the E1 …
of the ubl's C terminus. An E1's selectivity for its cognate ubl is essential because the E1 …