User profiles for Héctor Peinado
Hector PeinadoSpanish National Cancer Research Center (CNIO) Verified email at cnio.es Cited by 44537 |
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function
of melanoma-derived exosomes in the formation of primary tumors and metastases in …
of melanoma-derived exosomes in the formation of primary tumors and metastases in …
[HTML][HTML] Double-stranded DNA in exosomes: a novel biomarker in cancer detection
…, K Manova-Todorova, K Welte, J Bromberg, H Peinado… - Cell research, 2014 - nature.com
Exosomes, small membrane vesicles (30-100 nm) of endocytic origin secreted by most cell
types, contain functional biomolecules, which can be horizontally transferred to recipient cells …
types, contain functional biomolecules, which can be horizontally transferred to recipient cells …
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly
due to delayed detection. We hypothesized that intercellular communication is critical for …
due to delayed detection. We hypothesized that intercellular communication is critical for …
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
The heterogeneity of exosomal populations has hindered our understanding of their biogenesis,
molecular composition, biodistribution and functions. By employing asymmetric flow field…
molecular composition, biodistribution and functions. By employing asymmetric flow field…
Pre-metastatic niches: organ-specific homes for metastases
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …
tumour cells, but are instead selectively and actively modified by the primary tumour before …
The perivascular niche regulates breast tumour dormancy
In a significant fraction of breast cancer patients, distant metastases emerge after years or
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what …
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what …
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
The development of effective therapies against brain metastasis is currently hindered by
limitations in our understanding of the molecular mechanisms driving it. Here we define the …
limitations in our understanding of the molecular mechanisms driving it. Here we define the …
[HTML][HTML] ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells
…, S Sánchez-Redondo, H Peinado… - Nature …, 2020 - nature.com
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90%
of cancer-related deaths. The integrin ITGB3 has been previously described to play an …
of cancer-related deaths. The integrin ITGB3 has been previously described to play an …
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased. …
recently our knowledge of particular aspects of some of these processes has increased. …
The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts
Metastasis is a multistep process that requires acquisition of malignant cell phenotypes which
allow tumor cells to escape from the primary tumor site. Each of the steps during metastatic …
allow tumor cells to escape from the primary tumor site. Each of the steps during metastatic …