User profiles for Héctor Peinado

Hector Peinado

Spanish National Cancer Research Center (CNIO)
Verified email at cnio.es
Cited by 44537

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

H Peinado, M Alečković, S Lavotshkin, I Matei… - Nature medicine, 2012 - nature.com
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function
of melanoma-derived exosomes in the formation of primary tumors and metastases in …

[HTML][HTML] Double-stranded DNA in exosomes: a novel biomarker in cancer detection

…, K Manova-Todorova, K Welte, J Bromberg, H Peinado… - Cell research, 2014 - nature.com
Exosomes, small membrane vesicles (30-100 nm) of endocytic origin secreted by most cell
types, contain functional biomolecules, which can be horizontally transferred to recipient cells …

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

…, WR Jarnagin, RE Schwartz, I Matei, H Peinado… - Nature cell …, 2015 - nature.com
Pancreatic ductal adenocarcinomas (PDACs) are highly metastatic with poor prognosis, mainly
due to delayed detection. We hypothesized that intercellular communication is critical for …

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

…, J Blenis, R Schwartz, MS Brady, H Peinado… - Nature cell …, 2018 - nature.com
The heterogeneity of exosomal populations has hindered our understanding of their biogenesis,
molecular composition, biodistribution and functions. By employing asymmetric flow field…

Pre-metastatic niches: organ-specific homes for metastases

H Peinado, H Zhang, IR Matei, B Costa-Silva… - Nature Reviews …, 2017 - nature.com
It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …

The perivascular niche regulates breast tumour dormancy

CM Ghajar, H Peinado, H Mori, IR Matei, KJ Evason… - Nature cell …, 2013 - nature.com
In a significant fraction of breast cancer patients, distant metastases emerge after years or
even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what …

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

…, CM Rudin, DR Jones, PS Steeg, H Peinado… - Nature cell …, 2019 - nature.com
The development of effective therapies against brain metastasis is currently hindered by
limitations in our understanding of the molecular mechanisms driving it. Here we define the …

[HTML][HTML] ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

…, S Sánchez-Redondo, H Peinado… - Nature …, 2020 - nature.com
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90%
of cancer-related deaths. The integrin ITGB3 has been previously described to play an …

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

H Peinado, D Olmeda, A Cano - Nature reviews cancer, 2007 - nature.com
The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased. …

The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts

H Peinado, S Lavotshkin, D Lyden - Seminars in cancer biology, 2011 - Elsevier
Metastasis is a multistep process that requires acquisition of malignant cell phenotypes which
allow tumor cells to escape from the primary tumor site. Each of the steps during metastatic …