The retinoblastoma tumour suppressor (Rb) pathway is believed to have a critical role in the
control of cellular proliferation by regulating E2F activities 1 , 2 . E2F1, E2F2 and E2F3 …

Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …

We have used high-density DNA microarrays to provide an analysis of gene regulation
during the mammalian cell cycle and the role of E2F in this process. Cell cycle analysis was …

The tumour stroma is believed to contribute to some of the most malignant characteristics of
epithelial tumours. However, signalling between stromal and tumour cells is complex and …

Considerable evidence points to a role for Gl cyclin-dependent kinase (CDK) in allowing the
accumulation of E2F transcription factor activity and induction of the S phase of the cell …

The cyclin-dependent kinase (CDK)–RB–E2F axis forms the core transcriptional machinery
driving cell cycle progression, dictating the timing and fidelity of genome replication and …

Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal
cell growth control as well as during oncogenesis. We now show that Ras enhances the …

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize
epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different …

Previous work has demonstrated the important role of E2F transcription activity in the induction
of S phase during the transition from quiescence to proliferation. In addition to the E2F-…