Loss of the tumor suppressors RB1 and TP53 and MYC amplification are frequent oncogenic
events in small cell lung cancer (SCLC). We show that Myc expression cooperates with …

The major types of non-small-cell lung cancer (NSCLC)—squamous cell carcinoma and
adenocarcinoma—have distinct immune microenvironments. We developed a genetic model of …

Small cell lung cancer (SCLC) is one of the most deadly cancers and currently lacks effective
targeted treatment options. Recent advances in the molecular characterization of SCLC …

… Gurkan Mollaoglu … Gurkan Mollaoglu … Sánchez-Paulete, Jaime Mateus-Tique,
Gurkan Mollaoglu, Sebastian R. Nielsen, Adam Marks, Ashwitha Lakshmi, Jalal A. Khan, C. …

CLIC4 and CLIC1 are members of the well-conserved chloride intracellular channel proteins
(CLICs) structurally related to glutathione-S-transferases. Here, we report new roles of …

The cell surface is the cellular compartment responsible for communication with the environment.
The interior of mammalian cells undergoes dramatic reorganization when cells enter …

We asked young scientists: Are our schools and universities adequately prepared to educate
young people for future challenges? What is the most pressing issue in your field, and what …

Increasing evidence indicates oncogenes and tumor suppressors not only influence cell
fitness but can also control the immunophenotype of cells. Here, we examined how 34 …

Immune checkpoint blockade (ICB) has revolutionized the field of cancer immunology, yet
only 17-20% of patients who receive this treatment derive any clinical benefit. There is an …

Ovarian cancer (OvCa) is among the most aggressive and lethal cancers with a poor response
to immune checkpoint blockade (ICB) despite its modest tumor mutational burden and …