User profiles for Guillermo Abascal-Palacios

Guillermo Abascal-Palacios

The Institute of Cancer Research
Verified email at icr.ac.uk
Cited by 486

Structural basis of RNA polymerase III transcription initiation

G Abascal-Palacios, EP Ramsay, F Beuron, E Morris… - Nature, 2018 - nature.com
RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool
of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …

[HTML][HTML] Structure of human RNA polymerase III

EP Ramsay, G Abascal-Palacios, JL Daiß… - Nature …, 2020 - nature.com
In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and
other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across …

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

FJ Pérez-Victoria, G Abascal-Palacios… - Proceedings of the …, 2010 - National Acad Sciences
The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering
and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of …

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure

…, M Stuiver, G Abascal-Palacios… - Biochemical …, 2014 - portlandpress.com
Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg 2+
extruder at the renal distal convoluted tubule, or its regulator. In the present study, we …

[HTML][HTML] Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

…, K Kramm, O Dergai, G Abascal-Palacios… - Nature …, 2017 - nature.com
Initiation of gene transcription by RNA polymerase (Pol) III requires the activity of TFIIIB, a
complex formed by Brf1 (or Brf2), TBP (TATA-binding protein), and Bdp1. TFIIIB is required for …

[HTML][HTML] RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

YH Lin, M Lucas, TR Evans, G Abascal-Palacios… - PLoS …, 2018 - journals.plos.org
The eukaryotic ubiquitylation machinery catalyzes the covalent attachment of the small protein
modifier ubiquitin to cellular target proteins in order to alter their fate. Microbial pathogens …

[PDF][PDF] Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6

G Abascal-Palacios, C Schindler, AL Rojas… - Structure, 2013 - cell.com
The Golgi-Associated Retrograde Protein (GARP) complex is a tethering factor involved in
the fusion of endosome-derived transport vesicles to the trans-Golgi network through …

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans

…, FB Heiss, G Abascal-Palacios… - Life Science …, 2022 - life-science-alliance.org
Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major
determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we …

[HTML][HTML] Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes

G Abascal-Palacios, L Jochem, C Pla-Prats… - Nature …, 2021 - nature.com
Retrotransposons are endogenous elements that have the ability to mobilise their DNA
between different locations in the host genome. The Ty3 retrotransposon integrates with an …

A synthetic CRISPR-Cas nuclease with expanded enzymatic activities

…, M Gonzalez-Lopez, AM Aransay, G Abascal-Palacios… - bioRxiv, 2023 - biorxiv.org
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonucleases
have revolutionized biotechnology for their potential as programmable genome editors. …