User profiles for Guillermo Abascal-Palacios
Guillermo Abascal-PalaciosThe Institute of Cancer Research Verified email at icr.ac.uk Cited by 486 |
Structural basis of RNA polymerase III transcription initiation
RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool
of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
of transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
[HTML][HTML] Structure of human RNA polymerase III
EP Ramsay, G Abascal-Palacios, JL Daiß… - Nature …, 2020 - nature.com
In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and
other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across …
other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across …
Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex
FJ Pérez-Victoria, G Abascal-Palacios… - Proceedings of the …, 2010 - National Acad Sciences
The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering
and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of …
and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of …
Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure
…, M Stuiver, G Abascal-Palacios… - Biochemical …, 2014 - portlandpress.com
Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg 2+
extruder at the renal distal convoluted tubule, or its regulator. In the present study, we …
extruder at the renal distal convoluted tubule, or its regulator. In the present study, we …
[HTML][HTML] Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
…, K Kramm, O Dergai, G Abascal-Palacios… - Nature …, 2017 - nature.com
Initiation of gene transcription by RNA polymerase (Pol) III requires the activity of TFIIIB, a
complex formed by Brf1 (or Brf2), TBP (TATA-binding protein), and Bdp1. TFIIIB is required for …
complex formed by Brf1 (or Brf2), TBP (TATA-binding protein), and Bdp1. TFIIIB is required for …
[HTML][HTML] RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases
The eukaryotic ubiquitylation machinery catalyzes the covalent attachment of the small protein
modifier ubiquitin to cellular target proteins in order to alter their fate. Microbial pathogens …
modifier ubiquitin to cellular target proteins in order to alter their fate. Microbial pathogens …
[PDF][PDF] Structural basis for the interaction of the Golgi-Associated Retrograde Protein Complex with the t-SNARE Syntaxin 6
G Abascal-Palacios, C Schindler, AL Rojas… - Structure, 2013 - cell.com
The Golgi-Associated Retrograde Protein (GARP) complex is a tethering factor involved in
the fusion of endosome-derived transport vesicles to the trans-Golgi network through …
the fusion of endosome-derived transport vesicles to the trans-Golgi network through …
The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans
…, FB Heiss, G Abascal-Palacios… - Life Science …, 2022 - life-science-alliance.org
Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major
determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we …
determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we …
[HTML][HTML] Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes
G Abascal-Palacios, L Jochem, C Pla-Prats… - Nature …, 2021 - nature.com
Retrotransposons are endogenous elements that have the ability to mobilise their DNA
between different locations in the host genome. The Ty3 retrotransposon integrates with an …
between different locations in the host genome. The Ty3 retrotransposon integrates with an …
A synthetic CRISPR-Cas nuclease with expanded enzymatic activities
…, M Gonzalez-Lopez, AM Aransay, G Abascal-Palacios… - bioRxiv, 2023 - biorxiv.org
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonucleases
have revolutionized biotechnology for their potential as programmable genome editors. …
have revolutionized biotechnology for their potential as programmable genome editors. …