Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal
progenitors in vertebrates and invertebrates. However, the role of Wnt ligands in this …

The transcriptome is subject to rapid and massive changes during the transition between
developmental stages. These changes require tight control to avoid the undesired reactivation …

Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme involved in DNA repair and
transcription regulation, among other processes. Malignant transformations, tumor …

Metabolism, known to be temporally regulated to meet evolving energy demands, plays a
crucial role in shaping developmental pace. Recent studies have demonstrated that two key …

An individual’s gene expression profile changes throughout their life. This change in gene
expression is shaped by differences in physiological needs and functions between the …

To investigate the early stages of cell-cell interactions occurring between living biological
samples, imaging methods with appropriate spatiotemporal resolution are required. Among the …

Coordination of mitochondrial and nuclear processes is key to the cellular health; however,
very little is known about the molecular mechanisms regulating nuclear-mitochondrial …

Post-translational modification of nuclear proteins through the addition of poly(ADP-ribose) (pADPr)
moieties is upregulated in many metastatic cancers, where the high levels of pADPr …

PARP-1 is central to transcriptional regulation under both normal and stress conditions, with
the governing mechanisms yet to be fully understood. Our biochemical and ChIP-seq-based …

Transcription factors of the Zic family play important roles during animal development, and
their misregulation has been implicated in several human diseases. Zic proteins are present …