Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation

G Oliveros, CH Wallace, O Chaudry, Q Liu, Y Qiu, L Xie… - Brain, 2023 - academic.oup.com
Alzheimer’s disease is a multifactorial disease that exhibits cognitive deficits, neuronal loss,
amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. Hence, a multi-…

Timapiprant, a prostaglandin D2 receptor antagonist, ameliorates pathology in a rat Alzheimer's model

CH Wallace, G Oliveros, PA Serrano… - Life Science …, 2022 - life-science-alliance.org
We investigated the relevance of the prostaglandin D2 pathway in Alzheimer’s disease,
because prostaglandin D2 is a major prostaglandin in the brain. Thus, its contribution to …

[HTML][HTML] Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD …

CH Wallace, G Oliveros, L Xie, P Serrano… - Scientific Reports, 2024 - nature.com
Alzheimer’s disease (AD) is the major form of dementia prevalent in older adults and with a
high incidence in females. Identification of early biomarkers is essential for preventive …

Multi-scale predictive modeling discovers Ibudilast as a polypharmacological agent to improve hippocampal-dependent spatial learning and memory and mitigate …

G Oliveros, CH Wallace, O Chaudry, Q Liu, Y Qiu, L Xie… - bioRxiv, 2021 - biorxiv.org
Alzheimer’s disease (AD) is a multifactorial disease that exhibits cognitive deficits, neuronal
loss, amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. We …

Novel Therapeutic Strategies for Alzheimer's Disease: Targeting Toll-Like Receptor Signaling and a Multi-Target Approach

G Oliveros - 2022 - search.proquest.com
Giovanni Oliveros All Rights Reserved iii Novel therapeutic strategies for Alzheimer’s
disease: Targeting Toll-like receptor signaling and a multi-target approach by Giovanni Oliveros

Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and up regulates protective genes in an Alzheimer's transgenic rat model

C Wallace, G Oliveros, L Xie, P Serrano, P Rockwell… - bioRxiv, 2023 - biorxiv.org
Alzheimers disease (AD) is a multifactorial disease for which therapeutic efficacy should
benefit from a multi-target approach. Thus, we evaluated a combined chronic treatment with …

Prostaglandin D2 pathway in a transgenic rat model of Alzheimer's disease: therapeutic potential of timapiprant a DP2 antagonist

CH Wallace, G Oliveros, PA Serrano, P Rockwell, L Xie… - bioRxiv, 2022 - biorxiv.org
The cyclooxygenase pathway, a key mediator of inflammation, is implicated in Alzheimer’s
disease (AD). A deeper investigation is required into the contributions of this pathway to the …

Administrative Structure of the Sovereign State of Boyacá (1857-1886)

GF Amado-Oliveros - Estudios Socio-Jurídicos, 2009 - scielo.org.co
Abstract AMADO-OLIVEROS, Giovanni Fernando. Administrative Structure of the Sovereign
State of Boyacá (1857-1886). Estud. Socio-Juríd [online]. 2009, vol. 11, n. 1, pp. 145-179 …

Ibudilast in relapsing-remitting multiple sclerosis: a neuroprotectant?

F Barkhof, HE Hulst, J Drulovic, BMJ Uitdehaag… - Neurology, 2010 - AAN Enterprises
Background: Ibudilast is a phosphodiesterase inhibitor influencing inflammation and
neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and …

[HTML][HTML] Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats

O Chaudry, K Ndukwe, L Xie, M Figueiredo-Pereira… - Scientific Reports, 2022 - nature.com
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is most prevalent
in females. While estrogen provides neuroprotection in females, sex mediated differences …