The Cyclin-dependent kinase 1, as a serine/threonine protein kinase, is more than a cell cycle
regulator as it was originally identified. During the last decade, it has been shown to carry …

In Duchenne muscular dystrophy (DMD), the absence of the dystrophin protein causes a
variety of poorly understood secondary effects. Notably, muscle fibers of dystrophic individuals …

The term micro-heterogeneity refers to non-genetic cell to cell variability observed in a bell-shaped
distribution of the expression of a trait within a population. The contribution of micro-…

TO THE EDITOR 25-30% of younger adults with newly diagnosed acute myeloid leukemia (AML)
carry internal tandem duplications (ITDs) in the FLT3 gene [1]. ITD mutations regularly …

Fibro/Adipogenic Progenitors (FAPs) define a stem cell population playing a pro-regenerative
role after muscle damage. When removed from their natural niche, FAPs readily …

The insertion site of the internal tandem duplications (ITDs) in the FLT3 gene affects the
sensitivity to tyrosine kinase inhibitors (TKIs) therapy in acute myeloid leukemia (AML). Patients …

High throughput technologies such as deep sequencing and proteomics are increasingly
becoming mainstream in clinical practice and support diagnosis and patient stratification. …

Currently, the identification of patient-specific therapies in cancer is mainly informed by
personalized genomic analysis. In the setting of acute myeloid leukemia (AML), patient-drug …

The coronavirus disease 2019 (COVID-19) pandemic has caused more than 2.3 million
casualties worldwide and the lack of effective treatments is a major health concern. The …

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid
leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic …