Organoids are self‐organizing 3D structures grown from stem cells that recapitulate essential
aspects of organ structure and function. Here, we describe a method to establish long‐term…

In vitro 3D organoid systems have revolutionized the modeling of organ development and
diseases in a dish. Fluorescence microscopy has contributed to the characterization of the …

Respiratory infections are a major clinical problem, and treatment is increasingly complicated
by the emergence of microbial antibiotic resistance. Development of new antibiotics is …

Inflammatory diseases remain an important cause of morbidity and mortality. Cathelicidins
are immunomodulatory and antimicrobial peptides with potent anti-endotoxic properties. …

Adenine base editing (ABE) enables enzymatic conversion from AT into GC base pairs. ABE
holds promise for clinical application, as it does not depend on the introduction of double-…

Rationale: The generation of protective secretory IgA relies on the epithelial polymeric
immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive pulmonary …

Background Mesenchymal stromal cells (MSCs) are investigated for their potential to reduce
inflammation and to repair damaged tissue. Inflammation and tissue damage are hallmarks …

Basal cells play a critical role in the response of the airway epithelium to injury and are recently
recognized to also contribute to epithelial immunity. Antimicrobial proteins and peptides …

Antimicrobial proteins and peptides (AMPs) are a central component of the antibacterial
activity of airway epithelial cells. It has been proposed that a decrease in antibacterial lung …

It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed
respiratory epithelial defence proteins and thereby mucosal host defence. Localisation …