The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and
FTD remain controversial. We propose a model in which low-complexity (LC) domains of …

Protein aggregation is linked with neurodegeneration and numerous other diseases by
mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of …

Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and
other membrane-free organelles and is, in part, driven by the intrinsically disordered low-…

We present a method for predicting the regions of the sequences of peptides and proteins
that are most important in promoting their aggregation and amyloid formation. The method …

An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils
reveals that this structural form is likely to be the most stable one that protein molecules can …

Cellular chaperone networks prevent potentially toxic protein aggregation and ensure
proteome integrity. Here, we used Escherichia coli as a model to understand the organization of …

To the Editor: Only a small fraction of the human transcriptome (∼ 1%) encodes proteins1,
but a large portion of transcripts is long noncoding RNAs (lncRNAs) and is an unexplored …

Protein aggregation causes many devastating neurological and systemic diseases and
represents a major problem in the preparation of recombinant proteins in biotechnology. Major …

We have found that expression levels of human genes in vivo are remarkably anti-correlated
with the aggregation rates of the corresponding proteins measured in vitro by experiment. …

Here we introduce catRAPID omics, a server for large-scale calculations of protein–RNA
interactions. Our web server allows (i) predictions at proteomic and transcriptomic level; (ii) use …