User profiles for Gennaro De Libero

Gennaro De Libero

University of Basel
Verified email at unibas.ch
Cited by 13759

The immunology of CD1-and MR1-restricted T cells

L Mori, M Lepore, G De Libero - Annual review of immunology, 2016 - annualreviews.org
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells

…, L Angman, P Jenö, L Mori, G De Libero - The Journal of …, 2003 - rupress.org
T lymphocytes expressing the T cell receptor (TCR)-γδ recognize unknown antigens on
tumor cells. Here we identify metabolites of the mevalonate pathway as the tumor ligands that …

Recognition of lipid antigens by T cells

G De Libero, L Mori - Nature Reviews Immunology, 2005 - nature.com
Recent studies have shown that the recognition of lipid antigens by the immune system is
important for defence against infection and other diseases, and that lipid-specific responses …

Metformin as adjunct antituberculosis therapy

…, C Chee, G Kaplan, YT Wang, G De Libero - Science translational …, 2014 - science.org
The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential
new approach to TB therapy is to augment protective host immune responses. We report …

Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis

…, J Prandi, L Mori, G Puzo, G De Libero - The Journal of …, 2004 - rupress.org
Mycobacterial lipids comprise a heterogeneous group of molecules capable of inducing T cell
responses in humans. To identify novel antigenic lipids and increase our understanding of …

[HTML][HTML] Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

…, A Bertoletti, L Terracciano, G De Libero… - Nature …, 2014 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
conserved bacterial antigens derived from riboflavin precursors, presented by the non-polymorphic …

Point-of-care assays for tuberculosis: role of nanotechnology/microfluidics

SQ Wang, F Inci, G De Libero, A Singhal… - Biotechnology …, 2013 - Elsevier
Tuberculosis (TB) remains one of the most devastating infectious diseases and its eradication
is still unattainable given the limitations of current technologies for diagnosis, treatment …

High‐frequency and adaptive‐like dynamics of human CD1 self‐reactive T cells

…, C Garavaglia, L Mori, G De Libero… - European journal of …, 2011 - Wiley Online Library
CD1 molecules present lipid antigens to T cells. An intriguing subset of human T cells recognize
CD1‐expressing cells without deliberately added lipids. Frequency, subset distribution, …

Nonpeptide ligands for human gamma delta T cells.

…, S Sano, E Nieves, G De Libero… - Proceedings of the …, 1994 - National Acad Sciences
gamma delta T cells respond to a variety of microbial pathogens and transformed cells. Their
limited receptor repertoire and activation by mycobacterial antigens resistant to proteases …

Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells

…, M Olivo, J Rossjohn, L Mori, G De Libero - Nature …, 2013 - nature.com
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region
9 and δ-chain variable region 2 (V γ 9V δ 2) recognize phosphorylated prenyl metabolites …