Murine L929 fibrosarcoma cells treated with tumor necrosis factor (TNF) rapidly die in a
necrotic way, due to excessive formation of reactive oxygen intermediates. We investigated the …

Ischemia followed by reperfusion leads to severe organ injury and dysfunction. Inflammation
is considered to be the most important cause of tissue injury in organs subjected to ischemia…

Murine L929 fibrosarcoma cells were transfected with the human Fas (APO-1/CD95) receptor,
and the role of various caspases in Fas-mediated cell death was assessed. Proteolytic …

PITSLRE protein kinases are related to the large family of cyclin-dependent kinases. They
have been proposed to act as tumor suppressor genes and have been shown to play a role in …

Apoptosis and necrosis are two distinct forms of cell death. Caspases are indispensable as
initiators and effectors of apoptotic cell death and are involved in many of the morphological …

Caspase-14 belongs to a conserved family of aspartate-specific proteinases. Its expression
is restricted almost exclusively to the suprabasal layers of the epidermis and the hair follicles …

Homeostasis implies a balance between cell growth and cell death. This balance is
essential for the development and maintenance of multicellular organisms. Homeostasis is …

Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate–specific
proteinases, which are mainly involved in inflammation and apoptosis. However, …

Adult stem cells (SCs) are at high risk of accumulating deleterious mutations because they
reside and self-renew in adult tissues for extended periods. Little is known about how adult …

Caspase-14 is a protease that is mainly expressed in suprabasal epidermal layers and activated
during keratinocyte cornification. Caspase-14-deficient mice display reduced epidermal …