Sister chromatid cohesion, mediated by cohesin and regulated by Sororin, is essential for
chromosome segregation. In mammalian cells, cohesion establishment and Sororin …

Mouse models play an increasingly important role in the identification and functional assessment
of speech-associated genes, with a focus on genes involved in vocal production and …

Cohesin and cohesin regulatory proteins function in an essential pathway enabling proper
cohesion and segregation of sister chromatids. Additionally, these proteins are involved in …

In mitotic cells, establishment of sister chromatid cohesion requires acetylation of the cohesin
subunit SMC3 (acSMC3) by ESCO1 and/or ESCO2. Meiotic cohesin plays additional but …

Cohesin is a protein complex whose core subunits, Smc1, Smc3, Scc1, and SA1/SA2 form a
ring-like structure encircling the DNA. Cohesins play a key role in the expression, repair, …

Background Transgenic mice have become an important tool to elucidate the genetic
foundation of the human language faculty. While learning is an essential prerequisite for the …

A comprehensive account of the causes of alcohol misuse must accommodate individual
differences in biology, psychology and environment, and must disentangle cause and effect. …

Interferons induce cell-intrinsic responses associated with resistance to viral infection. To
overcome the suppressive action of interferons and their effectors, viruses have evolved …

The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing
the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a …

Telehealth, accessing healthcare and wellness remotely, should be a cost-effective and
efficient way for individuals to receive care. The convenience of having a reliable remote …