… active caspase in this mitochondrial fraction by Western blotting (van Loo et al., in preparation).
… mitochondria using a specific antiserum (G van Loo and P Vandenabeele, unpublished …

Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Apoptosis is a form of programmed cell death important in the development and tissue
homeostasis of multicellular organisms. Mitochondria have, next to their function in respiration, an …

Multiple lung pathogens such as chemical agents, H5N1 avian flu, or SARS cause high
lethality due to acute respiratory distress syndrome. Here we report that Toll-like receptor 4 (TLR4…

Murine L929 fibrosarcoma cells treated with tumor necrosis factor (TNF) rapidly die in a
necrotic way, due to excessive formation of reactive oxygen intermediates. We investigated the …

… f, g, Macroscopic and histological examination of colons from 8-week-old NEMO IEC-KO /MyD88
KO (f) and NEMO IEC-KO /TNFRI KO (g) mice reveal lack of colon inflammation in both …

Microglia have critical roles not only in neural development and homeostasis, but also in
neurodegenerative and neuroinflammatory diseases of the central nervous system 1 , 2 , 3 – 4 . …

Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal
bacteria, mucosal immune cells and intestinal epithelial cells (IECs) 1 , 2 , 3 , 4 . Epithelial …

… histological architecture in a control mouse (G) and liver tumors in 12-month-old NEMOLPC-KO
… We wish to thank G. Schü tz for the Alfp-Cre mice and C. Libbert for recombinant TNF. …

Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism
linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with …