β‐Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule
that in metazoans exerts a crucial role in a multitude of developmental and homeostatic …

The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental
contribution to metazoan development, tissue homeostasis and human malignancies. …

Wnt signalling, a key pathway involved in various aspects of embryonic development, also
underlies many human diseases, in particular, cancer. Research focused on signal …

… at 900 g for 10 min to obtain the nuclear pellet and the supernatant centrifuged at 130 000 g
… ‐EE monoclonal antibody), followed by protein G–Sepharose (Pharmacia), and then pelleted…

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors
of several cytokine signal transduction pathways. Their expression is induced by cytokine …

Cell-cell communication via Wnt signals represents a fundamental means by which animal
development and homeostasis are controlled. The identification of components of the Wnt …

The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails
the association of β-catenin with nuclear TCF/LEF proteins and results in transcriptional …

Wnt–β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium
by promoting stem cell renewal 1 , 2 . In the small intestine, epithelial Paneth cells secrete …

… The scale bars represent 100 μm in a and b, and 20 μm in c–g. … Morata and G. Struhl for
providing fly stocks and antibodies; B. Dickson and the VDRC team for providing RNAi lines; R. …

Targeting of Wnt signaling represents a promising anti-cancer therapy. However, the
consequences of systemically attenuating the Wnt pathway in an adult organism are unknown. Here…