The complement system was defined over a century ago based on its ability to “complement”
the antibody-mediated and cell-mediated immune responses against pathogens. Today …

The inflammasomes are intracellular multiprotein complexes that induce and regulate the
generation of the key pro‐inflammatory cytokines IL‐1β and IL‐18 in response to infectious …

… Arbore et al. now show that innate and adaptive immunity converge in human and mouse
T cells. Activated T cells express components of the complement cascade, which in turn leads …

… (G) CD46-BC1 isoform overexpression restores IFN-g upon TCR activation in Jurkat cells (n
… increase was accompanied by the induction of IFN-g production upon activation (Figure 1G). …

… C3a binds to the G protein-coupled receptor (GPCR) C3aR and C3b engages the complement
receptor and regulator CD46 8 . These receptors can be expressed intracellularly and …

… The lower panel is similar to the upper panel, except that G 2 … , we looked at the proportions
of S and G 2 /M cells in the 4 … a decreased proportion of S- and G 2 /M-phases compared …

… E and G, Volcano plots of proteins enriched in PanCK− (E) … E and G, Volcano plots of proteins
enriched in PanCK − (E) and … E and G, Volcano plots of proteins enriched in PanCK− (E) …

A fast antibody response can be critical to contain rapidly dividing pathogens. This can be
achieved by the expansion of antigen-specific B cells in response to T-cell help followed by …

LETTERS TO THE EDITOR 1151 secondary plasma C3–deficient patients (Fig 1, A), with
increased naive (CD19 1 IgD 1 CD27 2) B cells, and reduced unswitched (CD19 1 IgD 1 CD27 …

CD4+ T-helper 1 cell (Th1) function is closely regulated by an intrinsic developmental
program in which activation/induction and proinflammatory interferon (IFN)-γ secretion are …