The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG)
proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is …

Background Autophagy is the major intracellular degradation route in mammalian cells.
Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or …

Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly
of the oxidative phosphorylation complexes. This process requires temporal and spatial …

Background The composition of the matrix molecules is important in in vitro cell culture
experiments of eg. human cancer invasion and vessel formation. Currently, the mouse Engelbreth…

Mitophagy removes defective mitochondria via lysosomal elimination. Increased mitophagy
coincides with metabolic reprogramming, yet it remains unknown whether mitophagy is a …

Autophagy refers to the lysosomal degradation of damaged or superfluous components and
is essential for metabolic plasticity and tissue integrity. This evolutionarily conserved …

Mitochondrial fatty acid synthesis ( mtFAS ) shares acetyl‐ CoA with the K rebs cycle as a
common substrate and is required for the production of octanoic acid ( C 8) precursors of lipoic …

Mitochondria have a compartmentalized gene expression system dedicated to the synthesis
of membrane proteins essential for oxidative phosphorylation. Responsive quality control …

Mitochondrial fatty acid synthesis (mtFAS) is a highly conserved pathway essential for
mitochondrial biogenesis. The mtFAS process is required for mitochondrial respiratory chain …

The human nervous system matures over a protracted developmental time frame relative to
other species. What sets the pace of maturation has remained a mystery. In a recent …