In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and
protein synthesis in the cytoplasm poses the requirement of transporting thousands of …

The exon junction complex (EJC) plays a major role in posttranscriptional regulation of
mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the …

A prospective study was performed to establish whether infection with specific hepatitis C virus
(HCV) genotypes was associated with an increased risk of development of hepatocellular …

In mammals, Up-frameshift proteins (UPFs) form a surveillance complex that interacts with
the exon junction complex (EJC) to elicit nonsense-mediated mRNA decay (NMD). UPF3b is …

BACKGROUND & AIMS: Viral genotypes have been associated with different severity and
outcome of hepatitis C virus (HCV)-related liver disease. The aim of this study was to …

Several lines of evidence suggest that hepatitis C virus (HCV) core protein may modulate
cellular transduction signals and alter lipid metabolism. We have investigated the binding of …

Hepatitis C virus (HCV) infection persists for an indefinite length of time in a major proportion
of patients, inducing chronic liver lesions that evolve to cirrhosis and hepatocellular …

The exon junction complex (EJC) is deposited on mRNAs as a consequence of splicing and
influences postsplicing mRNA metabolism. The Mago–Y14 heterodimer is a core …

Efficient gene expression requires that, during their lifetime, mRNAs associate with different
sets of RNA binding proteins to form messenger ribonucleoprotein particles (mRNPs). The …

Cup is an eIF4E-binding protein (4E-BP) that plays a central role in translational regulation
of localized mRNAs during early Drosophila development. In particular, Cup is required for …