Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo
F Aoki, DM Worrad, RM Schultz - Developmental biology, 1997 - Elsevier
Transcription of endogenous genes in preimplantation 1- and 2-cell mouse embryos was
determined by monitoring the incorporation of BrUTP by plasma membrane-permeabilized …
determined by monitoring the incorporation of BrUTP by plasma membrane-permeabilized …
Changes in histone acetylation during mouse oocyte meiosis
JM Kim, H Liu, M Tazaki, M Nagata, F Aoki - The Journal of cell biology, 2003 - rupress.org
We examined global changes in the acetylation of histones in mouse oocytes during meiosis.
Immunocytochemistry with specific antibodies against various acetylated lysine residues …
Immunocytochemistry with specific antibodies against various acetylated lysine residues …
Regulation of histone H3 lysine 9 methylation in oocytes and early pre-implantation embryos
H Liu, JM Kim, F Aoki - 2004 - journals.biologists.com
Epigenetic modifications of the genome, such as covalent modification of histone residues,
ensure appropriate gene activation during pre-implantation development, and are probably …
ensure appropriate gene activation during pre-implantation development, and are probably …
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic transcription
is first detected shortly after pronucleus formation in 1‐cell embryos, but the identity of the …
is first detected shortly after pronucleus formation in 1‐cell embryos, but the identity of the …
Zygotic gene activation in mice: profile and regulation
F Aoki - Journal of Reproduction and Development, 2022 - jstage.jst.go.jp
The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial
activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late …
activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late …
[HTML][HTML] Alterations in epigenetic modifications during oocyte growth in mice
…, H Liu, N Kaneko, M Ooga, M Nagata, F Aoki - …, 2007 - rep.bioscientifica.com
During oocyte growth, chromatin structure is altered globally and gene expression is
silenced. To investigate the involvement of epigenetic modifications in the regulation of these …
silenced. To investigate the involvement of epigenetic modifications in the regulation of these …
Nucleolus precursor bodies and ribosome biogenesis in early mammalian embryos: old theories and new discoveries
H Fulka, F Aoki - Biology of Reproduction, 2016 - academic.oup.com
In mammals, mature oocytes and early preimplantation embryos contain transcriptionally
inactive structures termed nucleolus precursor bodies instead of the typical fibrillo-granular …
inactive structures termed nucleolus precursor bodies instead of the typical fibrillo-granular …
Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice
T Akiyama, M Nagata, F Aoki - Proceedings of the National …, 2006 - National Acad Sciences
Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions
and birth defects. Almost all such aneuploidy derives from meiotic errors in females, with …
and birth defects. Almost all such aneuploidy derives from meiotic errors in females, with …
Maturation/M-phase promoting factor: a regulator of aging in porcine oocytes
…, H Kaneko, M Yamashita, F Aoki… - Biology of …, 2000 - academic.oup.com
Deterioration in the quality of mammalian oocytes during the metaphase-II arrest period is
well known as “oocyte aging.” Oocytes in which aging has occurred are called aged oocytes, …
well known as “oocyte aging.” Oocytes in which aging has occurred are called aged oocytes, …
Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos
T Choi, F Aoki, M Mori, M Yamashita… - …, 1991 - journals.biologists.com
p34 cdc2 protein kinase is a universal regulator of M-phase in eukaryotic cell cycle. To
investigate the regulation of meiotic and mitotic cell cycle in mammals, we examined the changes …
investigate the regulation of meiotic and mitotic cell cycle in mammals, we examined the changes …